502159-01-5

Basic information

• Product Name: 2-HYDROXYPHENYLBORONIC ACID THP-ETHER
• Synonyms: 2-HYDROXYPHENYLBORONIC ACID THP-ETHER;2-(Tetrahydropyran-2-yloxy)phenylboronic acid;(3-tetrahydropyran-2-yloxyphenyl)boronic acid;Boronic acid, [2-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-;(2-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)boronic acid
• CAS NO: 502159-01-5
• Molecular Formula: C₁₁H₁₅BO₄
• Molecular Weight: 222.05
• Mol File: 502159-01-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-HYDROXYPHENYLBORONIC ACID THP-ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYPHENYLBORONIC ACID THP-ETHER(502159-01-5)
• EPA Substance Registry System: 2-HYDROXYPHENYLBORONIC ACID THP-ETHER(502159-01-5)

Safety Data

• Hazardous Substances Data: 502159-01-5(Hazardous Substances Data)

Usage

General Description

2-HYDROXYPHENYLBORONIC ACID THP-ETHER is a chemical compound that contains a boronic acid group and a tetrahydropyranyl (THP) ether group. It is commonly used as a reagent in organic synthesis and as a building block for pharmaceuticals and agrochemicals. The boronic acid group allows for the formation of stable complexes with diols, amines, and other nucleophiles, making it useful in Suzuki-Miyaura cross-coupling reactions and other organic transformations. The THP ether group provides protection for sensitive functional groups during synthesis and can be selectively removed under mild conditions. 2-HYDROXYPHENYLBORONIC ACID THP-ETHER is a versatile and widely used chemical with applications in various fields of chemistry.

Upstream product

• 4203-50-3 2-phenoxytetrahydropyran 
• 95-56-7 2-hydroxybromobenzene 
• 57999-46-9 2-(tetrahydropyran-2-yloxy)phenyl bromide 
• 5419-55-6 Triisopropyl borate 
• 108-95-2 phenol 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 934176-15-5 benzyl [2'-hydroxy-1,1'-biphenyl-3-yl]-acetate 
• 1026692-25-0 3'-[2-(benzyloxy)-2-oxoethyl]-1,1'-biphenyl-2-yl 3,4,5-trihydroxybenzoate 
• 934176-16-6 3'-[2-(benzyloxy)-2-oxoethyl]-1,1'-biphenyl-2-yl 3,4,5-tris(acetyloxy) benzoate 
• 1113040-41-7 2-(pyrrolidin-1-ylmethyl)-6-[2-(tetrahydro-2H-pyran-2-yloxy)phenyl]pyridine 
• 1113040-44-0 (2S)-N-tert-butyl-1-({6-[2-(tetrahydro-2H-pyran-2-yloxy)phenyl]pyridin-2-yl}methyl)pyrrolidine-2-carboxamide 
• 33421-36-2 2-(pyridine-2-yl)phenol 
• 1025884-50-7 benzyl [2'-(tetrahydro-2H-pyran-2-yloxy)-1,1'-biphenyl-3-yl]-acetate 
• 502159-04-8 2-[2-(tetrahydropyran-2-yloxy)-phenyl]pyridine 

Relevant articles and documents

Bimetal complex with aryloxy ether skeleton, and preparation method and application thereof

The invention provides a bimetallic complex with an aryloxy ether skeleton, and a preparation method and application of the bimetallic complex. The bimetallic complex has a structural expression as shown in the specification. A catalytic system of the bimetallic complex shows very good catalytic activity and thermal stability when being used for catalyzing olefin homopolymerization or olefin/alphaolefin copolymerization reactions, and a polymerization product generated by catalysis has relatively high molecular weight and a high alpha-olefin insertion rate and has a very good industrial application prospect.

Identification of Suitable Ligands for a Transition Metal-Catalyzed Reaction: Screening of a Modular Ligand Library in the Enantioselective Hydroboration of Styrene

Based on a general modular synthetic scheme, a variety of chiral bidentate P/P-, P/S-, P/N-, and P/Se-ligands is accessible in an efficient divergent manner starting from phenol or naphthol derived backbone systems. A library of 20 selected ligands was tested in the Rh-catalyzed asymmetric hydroboration of styrene to give 1-phenylethanol in up to 91% ee after oxidative work-up. It was demonstrated that small variations of the ligand structures lead to pronounced, unpredictable differences in the performance of the in situ generated rhodium complexes. The modular approach should be applicable for the identification and optimization of suitable ligands for other transition metal-catalyzed transformations with comparably low effort.