502421-33-2

Upstream product

• 143-33-9 sodium cyanide 
• 502421-28-5 2-chloro-3-methyl-6-pyridin-4-yl-5-(3-trifluoromethyl-phenyl)-3H-pyrimidin-4-one 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 208655-23-6 6-(4-pyridyl)-3-methyl-2-methylthio-5-(3-(trifluoromethyl)phenyl)-(3H)-pyrimidin-4-one 
• 100-48-1 pyridine-4-carbonitrile 
• 331-33-9 ethyl 3-trifluoromethylphenylacetate 

Relevant academic research and scientific papers

Substituted indolizine-like compounds and methods of use

Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Carbon-carbon bond construction at the 2-position of polysubstituted pyrimidinones

A novel synthetic method to introduce a carbon-carbon bond at the 2-position of pyrimidinones via nucleophilic addition of Grignard reagents to 2-cyano pyrimidinones at ambient conditions is disclosed. This unique approach leads to the preparation of such