50262-54-9

Usage

InChI:InChI=1/C10H10O4/c1-2-13-10(12)14-9-5-3-8(7-11)4-6-9/h3-7H,2H2,1H3

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1609-47-8 diethyl dicarbonate 

Downstream Products

• 34972-73-1 carbonic acid ethyl ester-[4-(2-nitro-vinyl)-phenyl ester] 
• 854179-22-9 carbonic acid ethyl ester-[4-(1-hydroxy-2-nitro-ethyl)-phenyl ester] 
• 112922-42-6 ethyl [p-[(E)-2-(5,6,7,8-tetrahydro-3-methoxy-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenyl]carbonate 
• 5884-67-3 armepavine 

Relevant academic research and scientific papers

Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

The role of two-pore channel 2 (TPC2), one of the few cation channels localized on endolysosomal membranes, in cancer remains poorly understood. Here, we report that TPC2 knockout reduces proliferation of cancer cells in vitro, affects their energy metabolism, and successfully abrogates tumor growth in vivo. Concurrently, we have developed simplified analogs of the alkaloid tetrandrine as potent TPC2 inhibitors by screening a library of synthesized benzyltetrahydroisoquinoline derivatives. Removal of dispensable substructures of the lead molecule tetrandrine increases antiproliferative properties against cancer cells and impairs proangiogenic signaling of endothelial cells to a greater extent than tetrandrine. Simultaneously, toxic effects on non-cancerous cells are reduced, allowing in vivo administration and revealing a TPC2 inhibitor with antitumor efficacy in mice. Hence, our study unveils TPC2 as valid target for cancer therapy and provides easily accessible tetrandrine analogs as a promising option for effective pharmacological interference.

BISPHOSPHONATE COMPOUNDS

Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism.

A new, mild, general and efficient route to aryl ethyl carbonates in solvent-free conditions promoted by magnesium perchlorate

A new, general and mild method for the direct synthesis of aryl and alkyl ethyl carbonates promoted by a Lewis acid is reported. The reaction proceeds smoothly with diethyl dicarbonate in the presence of Mg(ClO4) 2, a specific activator of 1,3-dicarbonyl compounds, and shows general applicability. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Novel tetrahydronaphthalene and indane derivatives

Novel styryl-tetrahydromaphythalene and indane derivatives useful for treating neoplasms and dermatoses.