50262-54-9

Basic information

• Product Name: Carbonic acid ethyl 4-formylphenyl ester
• Synonyms: Carbonic acid ethyl 4-formylphenyl ester
• CAS NO: 50262-54-9
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 50262-54-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 314.1°Cat760mmHg
• Flash Point: 138.7°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 0.000475mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: Carbonic acid ethyl 4-formylphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonic acid ethyl 4-formylphenyl ester(50262-54-9)
• EPA Substance Registry System: Carbonic acid ethyl 4-formylphenyl ester(50262-54-9)

Safety Data

• Hazardous Substances Data: 50262-54-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10O4/c1-2-13-10(12)14-9-5-3-8(7-11)4-6-9/h3-7H,2H2,1H3

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 1609-47-8 diethyl dicarbonate 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 112922-42-6 ethyl [p-[(E)-2-(5,6,7,8-tetrahydro-3-methoxy-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenyl]carbonate 
• 5884-67-3 armepavine 
• 34972-73-1 carbonic acid ethyl ester-[4-(2-nitro-vinyl)-phenyl ester] 
• 854179-22-9 carbonic acid ethyl ester-[4-(1-hydroxy-2-nitro-ethyl)-phenyl ester] 

Relevant articles and documents

Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

The role of two-pore channel 2 (TPC2), one of the few cation channels localized on endolysosomal membranes, in cancer remains poorly understood. Here, we report that TPC2 knockout reduces proliferation of cancer cells in vitro, affects their energy metabolism, and successfully abrogates tumor growth in vivo. Concurrently, we have developed simplified analogs of the alkaloid tetrandrine as potent TPC2 inhibitors by screening a library of synthesized benzyltetrahydroisoquinoline derivatives. Removal of dispensable substructures of the lead molecule tetrandrine increases antiproliferative properties against cancer cells and impairs proangiogenic signaling of endothelial cells to a greater extent than tetrandrine. Simultaneously, toxic effects on non-cancerous cells are reduced, allowing in vivo administration and revealing a TPC2 inhibitor with antitumor efficacy in mice. Hence, our study unveils TPC2 as valid target for cancer therapy and provides easily accessible tetrandrine analogs as a promising option for effective pharmacological interference.

A new, mild, general and efficient route to aryl ethyl carbonates in solvent-free conditions promoted by magnesium perchlorate

A new, general and mild method for the direct synthesis of aryl and alkyl ethyl carbonates promoted by a Lewis acid is reported. The reaction proceeds smoothly with diethyl dicarbonate in the presence of Mg(ClO4) 2, a specific activator of 1,3-dicarbonyl compounds, and shows general applicability. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.