502649-73-2

Usage

Uses

Used in Fragrance and Flavoring Industry:
Methyl 2-(3-iodophenyl)acetate is used as a key ingredient for creating distinctive scents and flavors in fragrances and flavorings. Its unique odor and versatility make it a valuable component in the development of various scent and taste profiles.
Used in Pharmaceutical Industry:
Methyl 2-(3-iodophenyl)acetate is used as a building block in the synthesis of pharmaceuticals. Its chemical properties allow it to be incorporated into the structure of various drugs, contributing to their efficacy and therapeutic potential.
Used in Agrochemical Industry:
Methyl 2-(3-iodophenyl)acetate is used as a key component in the development of agrochemicals. Its ability to be synthesized into various organic compounds makes it a valuable asset in the creation of pesticides, herbicides, and other agricultural products.
Used in Polymer and Resin Industry:
Methyl 2-(3-iodophenyl)acetate is used as an intermediate in the manufacture of polymers and resins. Its chemical properties enable it to be incorporated into the production process, resulting in the creation of various types of polymers and resins with specific properties and applications.
Used in Dye Industry:
Methyl 2-(3-iodophenyl)acetate is used as a precursor in the synthesis of dyes. Its ability to be transformed into different chemical structures allows it to be used in the production of a wide range of dyes with varying colors and properties.

Upstream product

• 67-56-1 methanol 
• 618-51-9 3-Iodobenzoic acid 
• 16695-14-0 Malonic acid monomethyl ester 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 1878-69-9 3-iodophenylacetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1191447-01-4 methyl 2-[3'-(6''-hydroxyhex-1''-ynyl)phenyl]acetate 
• 1191446-95-3 methyl 2-{3'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16'''β-yl)tridec-1-ynyl]phenyl}acetate 
• 1395060-01-1 C₂₆H₂₃NO₃ 
• 1395060-34-0 methyl 2-(3-(5,11-dihydro-2-ethyl-5-methyl-11-methylene-6-oxodibenz[b,e]azepin-8-yl)phenyl)acetate 
• 1254580-41-0 (Z)-(3-pent-3-enylphenyl)acetic acid methyl ester 
• 1372403-89-8 (E)-(3-pent-3-enylphenyl)acetic acid methyl ester 
• 1254580-40-9 [3-(3-oxopropyl)phenyl]acetic acid methyl ester 
• 1254580-39-6 [3-(3-hydroxypropyl)phenyl]acetic acid methyl ester 
• 1254580-38-5 [3-(3-hydroxyprop-1-ynyl)phenyl]acetic acid methyl ester 
• 1218999-64-4 methyl 2-(3-iodophenyl)propanoate 
• 1218999-71-3 methyl 3-(2-chloropyridin-4-yl)phenylacetate 
• 1097731-43-5 methyl (3-{2'-[3''-(tert-butoxycarbonylamino-methyl)-phenyl]-vinyl}-phenyl)acetate 
• 1002101-17-8 methyl (3-(pentyn-1-yl)phenyl)acetate 
• 861857-76-3 methyl 2-(3-iodophenyl)-2-methylpropanoate 

Relevant academic research and scientific papers

Silylium-Catalyzed Carbon–Carbon Coupling of Alkynylsilanes with (2-Bromo-1-methoxyethyl)arenes: Alternative Approaches

The catalytic activation of alkynylsilanes towards 2-halo-1-alkoxyalkyl arenes gives β-halo-substituted alkynes. It involves the chemoselective substitution of an alkoxide by an alkyne in the presence of a neighboring C(sp3)–Br bond in a cationic C–C bond-forming event. Two complementary protocols to accomplish this new transformation are reported. The outcome of a direct approach based on mixing the precursors with a freshly prepared solution of the active catalytic species (TMSNTf2) is compared with an alternative based on smooth release of the required silylium ions upon selective activation of the alkyne by gold(I) (JohnPhosAuNTf2). The two approaches gave satisfactory results to access this otherwise elusive alkynylation process, which furnishes 4-bromo-substituted alkynes and tolerates various functional groups.

OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS

Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.

Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis

We report decarboxylative carbonyl α-arylation by coupling of arylboron nucleophiles with malonic acid derivatives. This process is enabled by the merger of aerobic oxidative Cu catalysis with decarboxylative enolate interception reminiscent of malonyl-CoA reactivity in polyketide biosynthesis. This method enables the synthesis of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible with existing α-arylation reactivity paradigms. The utility of the reaction is demonstrated in drug intermediate synthesis and late-stage functionalization.

Design, synthesis, and biological evaluation of novel transrepression- selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11- methylene-6 H-dibenz[ b, e ]azepin-6-one skeleton

To obtain novel transrepression-selective liver X receptor (LXR) ligands, we adopted a strategy of reducing the transactivational agonistic activity of the 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one derivative 10, which exhibits LXR-mediated transrepressional and transactivational activity. Structural modification of 10 based on the reported X-ray crystal structure of the LXR ligand-binding domain led to a series of compounds, of which almost all exhibited transrepressional activity at 1 or 10 μM but showed no transactivational activity even at 30 μM. Among the compounds obtained, 18 and 22 were confirmed to have LXR-dependent transrepressional activity by using peritoneal macrophages from wild-type and LXR-null mice. A newly developed fluorescence polarization assay indicated that they bind directly to LXRα. Next, further structural modification was performed with the guidance of docking simulations with LXRα, focusing on enhancing the binding of the ligands with LXRα through the introduction of substituents or heteroatom(s). Among the compounds synthesized, compound 48, bearing a hydroxyl group, showed potent, selective, and dose-dependent transrepressional activity.

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

A novel class of phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore attached to its C-2, C-3 or C-4 position was designed for evaluation as anti-inflammatory (AI) agents. A number of compounds exhibited a com

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF

The present invention relates to substituted aromatic compounds of Formula (I) and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.

Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol-adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

A series of estradiol (E2) derivatives were designed to interact with, both the substrate- and the cofactor-binding sites of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1). These analogues of potent E2-adenosine hybrid inhibitor EM-1745, where the adenosine moiety was replaced by a more stable benzene derivative, were synthesized from estrone using alkene cross-metathesis and Sonogashira coupling reactions as key steps. In vitro biological evaluation of these steroid derivatives revealed that a spacer of 13 methylenes, between the 16β-position of E2 and the adenosine mimic bearing a carboxylic acid, group, gave the best inhibition of 17β-HSD1.

Chemistry and folding of photomodulable peptides - Stilbene and thioaurone-type candidates for conformational switches

Optimized synthetic strategies for the preparation of photoswitchable molecular scaffolds based on stilbene or on thioaurone chromophores and their conformationally directing properties, as studied by computations and by NMR spectroscopy, are addressed. For the stilbene peptidomimetics 1, 2 and 3, the length of connecting linkers between the chromophore and the peptide strands was varied, resulting in photochromic dipeptidomimetics with various flexibility. Building blocks of higher rigidity, based on para-substituted thioaurone (4 and 6) and meta-substituted thioaurone chromophores (5 and 7) are shown to have a stronger conformationally directing effect. Design, synthesis, theoretical and experimental conformational analyses are presented.

SUBSTITUTED UREA AND CARBAMATE, PHENACYL-2-HYDROXY-3-DIAMINOALKANE, AND BENZAMIDE-2-HYDROXY-3-DIAMINOALKANE ASPARTYL-PROTEASE INHIBITORS

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.