502925-67-9Relevant articles and documents
Bioconjugated rhenium(I) complexes with amino acid derivatives: Synthesis, photophysical properties, and cell imaging studies
Fernandez-Moreira, Vanesa,Ortego, M. Lourdes,Williams, Catrin F.,Coogan, Michael P.,Villacampa, M. Dolores,Gimeno, M. Concepcion
, p. 5950 - 5957 (2012)
The synthesis of a series of bioconjugated fac tricarbonyl rhenium bis-imine complexes with amino acid ester derivatives and their application in fluorescent microscopy cell imaging is reported. A range of meta- and para-bioconjugated pyridyl derivatives were synthesized, and their photophysical properties were analyzed upon coordination to fac-[Re(bipy)(CO) 3(CF3SO3)]. Their long lifetimes (270-370 ns) and large Stokes shifts (>140 nm) suggested the new bioconjugated rhenium complexes could be strong candidates for cell imaging applications. All species were taken up by MCF-7 cells and seemed to have a distinct localization pattern. However, while cells incubated with para derivatives had an anomalous cellular growth pattern and suffered from photobleaching upon irradiation, promoting cellular death, those incubated with the meta derivatives behaved in a normal manner and did not photobleach, emphasizing the importance of the ligand design when it is necessary to have an optimum outcome: i.e., cell imaging or phototherapy applications.
Microwave-assisted synthesis and antimicrobial activity of some novel isatin schiff bases linked to nicotinic acid via certain amino acid bridge
Naglah, Ahmed M.,Awad, Hassan M.,Bhat, Mashooq A.,Al-Omar, Mohamed A.,Amr, Abd El-Galil E.
, (2015)
The coupling reaction of nicotinic acid with certain L-amino acid methyl esters including valine, leucine, and phenylalanine was done by the use of acid chloride method. The products were reacted with hydrazine hydrate 99% to give the corresponding hydraz
A convenient and efficient synthesis of dipeptidyl benzoxaboroles and their peptidomimetics
Fu, Zhengyan,He, Jiangpeng,Tong, Aiping,Xie, Yongmei,Wei, Yuquan
supporting information, p. 2843 - 2852 (2013/10/22)
We have developed a convenient and efficient method for the synthesis of dipeptidyl benzoxaboroles and their peptidomimetics. The novel dipeptidyl benzoxaboroles were obtained by the protecting-group-free coupling of 6-amino-1,3-dihydro-2,1-benzoxaborol-1-ol with various N-(arylcarbonyl) phenylalanines. Bioisosteric replacement of the terminal amide moiety of dipeptidyl benzoxaboroles by 1,3,4-oxadiazoles or 4H-3,1-benzothiazin-4-one provided their peptidomimetics with good molecular diversity. These transformations were based on the pluripotency of methyl (S)-2-isothiocyanato-3- phenylpropanoate and were highlighted by mild reaction conditions, high atom efficiency, and good to excellent isolated yields. This method is a valuable addition to the development of novel drug-like boronic acid molecules. Georg Thieme Verlag Stuttgart ? New York.
Photoinduced intramolecular tryptophan oxidation and excited-state behavior of [Re(L-AA)(CO)3(α-diimine)]+ (L = pyridine or imidazole, AA = tryptophan, tyrosine, phenylalanine)
Blanco-Rodriguez, Ana Maria,Towrie, Mike,Sykora,Zalis, Stanislav,Vlcek, Antonin
experimental part, p. 6122 - 6134 (2011/08/22)
ReI carbonyl-diimine complexes [Re(L-AA)(CO)3(N,N)] + (N,N = bpy, phen) containing an aromatic amino acid (AA), phenylalanine (Phe), tyrosine (Tyr), or tryptophan (Trp), linked to Re by a pyridine-amido or imidazole-amido
Unusual temperature dependence of enantioselectivity in asymmetric reductions by chiral NADH models
Saito, Ryota,Naruse, Shoichiro,Takano, Koji,Fukuda, Keiko,Katoh, Akira,Inoue, Yoshihisa
, p. 2067 - 2070 (2007/10/03)
Unusual stereoselectivity changes, i.e., enhancement and inversion of enantioselectivity with increasing temperature, were observed in the asymmetric reduction of methyl benzoylformate with chiral 1,4-dihydropyridines possessing amino acid residues as lig
