503072-28-4Relevant academic research and scientific papers
The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones
Laufersweiler, Matthew J.,Brugel, Todd A.,Clark, Michael P.,Golebiowski, Adam,Bookland, Roger G.,Laughlin, Steven K.,Sabat, Mark P.,Townes, Jennifer A.,VanRens, John C.,De, Biswanath,Hsieh, Lily C.,Heitmeyer, Sandra A.,Juergens, Karen,Brown, Kimberly K.,Mekel, Marlene J.,Walter, Richard L.,Janusz, Michael J.
, p. 4267 - 4272 (2004)
Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-α (TNF-α) production. Many of these compounds show low nanomolar activity against lipopolysaccaride (LPS)-induced TNF-α production in THP-1 cells. This clas
