503072-73-9Relevant academic research and scientific papers
6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
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, (2008/06/13)
The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the for
The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones
Laufersweiler, Matthew J.,Brugel, Todd A.,Clark, Michael P.,Golebiowski, Adam,Bookland, Roger G.,Laughlin, Steven K.,Sabat, Mark P.,Townes, Jennifer A.,VanRens, John C.,De, Biswanath,Hsieh, Lily C.,Heitmeyer, Sandra A.,Juergens, Karen,Brown, Kimberly K.,Mekel, Marlene J.,Walter, Richard L.,Janusz, Michael J.
, p. 4267 - 4272 (2007/10/03)
Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-α (TNF-α) production. Many of these compounds show low nanomolar activity against lipopolysaccaride (LPS)-induced TNF-α production in THP-1 cells. This clas
