503090-99-1 Usage
Uses
Used in Pharmaceutical Manufacturing:
Naltrexone EP Impurity H is used as a controlled substance in the production of naltrexone to ensure the minimization of impurities. This is crucial for maintaining the drug's purity, safety, and efficacy, as the presence of Impurity H can potentially affect the therapeutic outcomes of naltrexone treatment for patients with alcohol and opioid dependence.
In the pharmaceutical industry, the focus on minimizing Naltrexone EP Impurity H is driven by the need to adhere to regulatory standards and to protect patient health. The impurity control measures are implemented during the synthesis and purification stages of naltrexone production, employing various analytical techniques and quality control processes to detect and reduce the levels of Impurity H to acceptable limits. This ensures that the final drug product meets the required pharmaceutical quality and safety standards, providing effective treatment options for individuals struggling with substance dependence.
Check Digit Verification of cas no
The CAS Registry Mumber 503090-99-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,3,0,9 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 503090-99:
(8*5)+(7*0)+(6*3)+(5*0)+(4*9)+(3*0)+(2*9)+(1*9)=121
121 % 10 = 1
So 503090-99-1 is a valid CAS Registry Number.
503090-99-1Relevant academic research and scientific papers
Selfridge, Brandon R.,Wang, Xiaohui,Zhang, Yingning,Yin, Hang,Grace, Peter M.,Watkins, Linda R.,Jacobson, Arthur E.,Rice, Kenner C.
, p. 5038 - 5052 (2015)
Activation of Toll-like receptors has been linked to neuropathic pain and opioid dependence. (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. We designed and synthesized compoun
