503130-83-4Relevant academic research and scientific papers
Synthesis of trisubstituted indoles on the solid phase via palladium-mediated heteroannulation of internal alkynes
Zhang, Han-Cheng,Brumfield, Kimberly K.,Maryanoff, Bruce E.
, p. 2439 - 2442 (1997)
Palladium-mediated heteroannulation of internal alkynes with resin-bound o-iodoaniline derivatives 4 or 5a provided diverse trisubstituted indoles 6 in good yields. The facile reaction of trimethylsilylalkynes afforded resin-bound precursors useful for obtaining other 2-substituted indole derivatives, such as 12.
Solid-phase synthesis of an A-B loop mimetic of the Cε3 domain of human IgE: Macrocyclization by Sonogashira coupling
Spivey, Alan C.,McKendrick, John,Srikaran, Ratnasothy,Helm, Birgit A.
, p. 1843 - 1851 (2007/10/03)
The solid-phase synthesis of a cyclic peptide containing the 21-residue epitope found in the A-B loop of the Cε3 domain of human immunoglobulin E has been carried out. The key macrocyclization step to form the 65-membered ring is achieved in ～15% yield vi
