Synthesis of trisubstituted indoles on the solid phase via palladium-mediated heteroannulation of internal alkynes

Article abstract of DOI:10.1016/S0040-4039(97)00417-6

Palladium-mediated heteroannulation of internal alkynes with resin-bound o-iodoaniline derivatives 4 or 5a provided diverse trisubstituted indoles 6 in good yields. The facile reaction of trimethylsilylalkynes afforded resin-bound precursors useful for obtaining other 2-substituted indole derivatives, such as 12.