503130-84-5Relevant academic research and scientific papers
Concise synthesis of cyclic carbonyl compounds from haloarenes using phenyl formate as the carbonyl source
Konishi, Hideyuki,Nagase, Hiroki,Manabe, Kei
supporting information, p. 1854 - 1857 (2015/01/30)
Various cyclic carbonyl compounds were concisely synthesized by carbonylative cyclization of haloarenes bearing nucleophilic moieties under Pd catalysis. A broad substrate scope and a feasible large-scale synthesis clearly demonstrate the high applicability of the reaction as a general, user-friendly method for access to cyclic carbonyl compounds.
Cu-catalyzed in situ generation of thiol using xanthate as a thiol surrogate for the one-pot synthesis of benzothiazoles and benzothiophenes
Prasad,Sekar
supporting information, p. 1659 - 1665 (2013/03/28)
A new copper-catalyzed in situ generation of aryl thiolates strategy was successfully developed for the one-pot synthesis of substituted benzothiazoles from 2-iodoanilides using xanthate as a thiol precursor. A wide range of 2-iodoanilides with both electron-releasing and electron-withdrawing groups produced the corresponding benzothiazoles in good yields. Further, this one-pot protocol was successfully utilized for the synthesis of a potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzo[d]thiazole (PMX 610). Finally, the copper-catalyzed in situ generation of aryl thiolates strategy was successfully applied for the domino synthesis of substituted benzothiophenes from o-haloalkynyl benzenes using xanthate as a thiol precursor.
Design and synthesis of 1-benzazepine derivatives by strategic utilization of Suzuki-Miyaura cross-coupling, aza-Claisen rearrangement and ring-closing metathesis
Kotha, Sambasivarao,Shah, Vrajesh R.
scheme or table, p. 1054 - 1064 (2009/04/05)
A new and simple methodology has been realized for the synthesis of 7-substituted 2,3,4,5-tetrahydro-1-benzazepine derivatives with Suzuki-Miyaura cross-coupling, aza-Claisen rearrangement and ring-closing metathesis (RCM) the key steps. Here, o-allylacet
Solid-phase synthesis of an A-B loop mimetic of the Cε3 domain of human IgE: Macrocyclization by Sonogashira coupling
Spivey, Alan C.,McKendrick, John,Srikaran, Ratnasothy,Helm, Birgit A.
, p. 1843 - 1851 (2007/10/03)
The solid-phase synthesis of a cyclic peptide containing the 21-residue epitope found in the A-B loop of the Cε3 domain of human immunoglobulin E has been carried out. The key macrocyclization step to form the 65-membered ring is achieved in ～15% yield vi
