503155-67-7 Usage
Uses
Used in Scientific Research:
2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide is used as a research compound for its unique structural features and potential applications in various scientific studies. Its complex nature and the presence of multiple functional groups make it a candidate for exploration in fields such as organic chemistry, medicinal chemistry, and materials science.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide may be utilized as a lead compound in drug discovery. Its structural components, such as the tetrazoles and biphenyls, could be key in the development of new therapeutic agents, particularly in areas where novel chemical entities are needed to address unmet medical needs.
Used in Material Science:
2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide could also be employed in material science applications, where its unique chemical structure may contribute to the development of new materials with specific properties. These materials could be used in various industries, such as electronics, where novel compounds with tailored characteristics are constantly sought after.
Check Digit Verification of cas no
The CAS Registry Mumber 503155-67-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,3,1,5 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 503155-67:
(8*5)+(7*0)+(6*3)+(5*1)+(4*5)+(3*5)+(2*6)+(1*7)=117
117 % 10 = 7
So 503155-67-7 is a valid CAS Registry Number.
503155-67-7Relevant academic research and scientific papers
Process for Preparation of Fimasartan and Intermediate for Preparing the Same
-
, (2020/10/20)
The present invention relates to a simple and economically process for preparing fimasartan and its preparation intermediates. (by machine translation)
Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists
Kim, Tae Woo,Yoo, Byoung Wook,Lee, Joon Kwang,Kim, Ji Han,Lee, Kyung-Tae,Chi, Yong Ha,Lee, Jae Yeol
, p. 1649 - 1654 (2012/04/04)
The discovery, in vitro and in vivo studies of the highly potent AT1 antagonist 12a (BR-A-657, Fimasartan) are presented. A series of pyrimidin-4(3H)-one derivatives as losartan analogue were synthesized and evaluated for a novel class of AT1 receptor antagonists. Among them, 12a containing thioamido moiety displayed both high in vitro functional antagonism and binding affinity [IC50 = 0.42 and 0.13 nM, respectively] and inhibited strongly in vivo AngII-induced pressor response in pithed rats with an ED50 of 0.018 mg/kg. Moreover, in vivo evaluation in furosemide-treated rat and conscious renal hypertensive rat models and the pharmacokinetic study showed that 12a is a highly potent and orally active AT1 selective antagonist having stronger in vivo potency than losartan.
