503178-23-2Relevant academic research and scientific papers
A mild and efficient approach for the deprotection of silyl ethers by sodium periodate
Wang, Mijuan,Li, Chun,Yin, Dali,Liang, Xiao-Tian
, p. 8727 - 8729 (2002)
A mild and efficient method for the deprotection of silyl ethers is reported. The most often used silyl protecting groups, such as TBDMS, TIPS, TMS, TES, TIBS, TPS can be cleaved by NaIO4 furnishing the corresponding alcohol in high yields. This method can be used for a wide range of substrates.
A chemoenzymatic approach to chiral phenylisoserinates using 4-isopropyl-2-oxazolin-5-one as masked umpoled synthon for hydroxycarbonyl anion
Barco, Achille,Benetti, Simonetta,De Risi, Carmela,Pollini, Gian P.,Romagnoli, Romeo,Zanirato, Vinicio
, p. 9289 - 9292 (2007/10/02)
The aldol adduct between the anion of 4-isopropyl-2-oxazolin-5-one with racemic N-(tertbutoxycarbonyl)-phenylglycinal underwent concomitant isomerization and ring cleavage under mild basic conditions producing the racemic dipeptide N-Boc-phenylisoserine-v
Chiral Auxiliary-Mediated Asymmetric Induction in a Thermal Inverse Electron Demand Hetero-Diels-Alder Reaction. Enantioselective Synthesis of the Taxol A-Ring Side Chain
Swindell, Charles S.,Tao, Ming
, p. 5889 - 5891 (2007/10/02)
Chiral auxiliary-modified ketene acetal 5g and N-benzoylbenzaldimine (4) engage in an endo and ?-facially selective thermal inverse electron demand hetero-Diels-Alder reaction that is the key step in a synthesis of enantiomerically pure taxol A-ring side-chain methyl ester 9.
Anitleukemic Alkaloids from Taxus wallichiana Zucc.
Miller, Roger W.,Powell, Richard G.,Smith, Cecil R.
, p. 1469 - 1474 (2007/10/02)
A new antileukemic taxane alkaloid, cephalomannine (1a), has been isolated from leaves, stems, and roots of Taxus wallichiana Zucc.Cephalomannine is closely related to taxol (1b), a previously characterized antileukemic alkaloid, which also occurs in T. wallichiana but in lesser amounts than cephalomannine.The new alkaloid and its hydrolysis products were characterized by nuclear magnetic resonance, mass spetroscopy, and X-ray crystallography; taxol and two cytotoxic taxane congeners were also identified.
