503269-75-8

Upstream product

• 1499-21-4 Diphenylphosphinic chloride 
• 33070-32-5 5-bromo-2,2-difluoro-2H-1,3-benzodioxole 
• 503269-73-6 (2,2-difluoro-1,3-benzodioxol-5-yl)diphenylphosphane oxide 
• 503269-74-7 (2,2-difluoro-4-iodo-1,3-benzodioxol-5-yl)diphenylphosphane oxide 

Downstream Products

• 503538-69-0 (R)-(-)-5,5’-bis(diphenyl;phosphine)-2,2,2’,2’-tetrafluoro-4,4’-bi-1,3-benzodioxole 

Relevant academic research and scientific papers

Difluorphos, an Electron-Poor Disphosphane: A Good Match between Electronic and Steric Features

The π acidity makes the difference: The fluorinated diphosphane, difluorphos, is synthesized (see structure: purple = P, red = O, green = F, gray = C) and its stereoelectronic features are evaluated in theoretical and experimental studies. Its unusual π acidity explains the excellent results obtained with it in ruthenium-mediated asymmetric hydrogenation of fluorinated β-functionalized ketones. These results are better than those obtained with other biphenyl-based diphosphanes.

Novel diphosphines, their complexes with transisition metals and their use in asymmetric synthesis

The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): in which: R1 and R2 are a (C5-C7)cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; and A is (CH2—CH2) or CF2. The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).