503303-81-9Relevant academic research and scientific papers
Convergent synthesis of 2,3-bisarylpyrazolones through cyclization of bisacylated pyrazolidines and hydrazines
Brugel, Todd A.,Hudlicky, Tomas,Clark, Michael P.,Golebiowski, Adam,Sabat, Mark,Endoma, Mary Ann A.,Bui, Vu,Adams, David,Laufersweiler, Matthew J.,Maier, Jennifer A.,Bookland, Roger G.,De, Biswanath
, p. 3195 - 3198 (2007/10/03)
Cyclization of various bisacylated hydrazines and pyrazolidines using DBU or sodium hydride leads to the formation of various mono-, bi- and tricyclic pyrazolone scaffolds in 41-98% yield. The convergent nature by which the precyclization intermediates are constructed allows for rapid derivatization about the pyrazolone core.
The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones
Laufersweiler, Matthew J.,Brugel, Todd A.,Clark, Michael P.,Golebiowski, Adam,Bookland, Roger G.,Laughlin, Steven K.,Sabat, Mark P.,Townes, Jennifer A.,VanRens, John C.,De, Biswanath,Hsieh, Lily C.,Heitmeyer, Sandra A.,Juergens, Karen,Brown, Kimberly K.,Mekel, Marlene J.,Walter, Richard L.,Janusz, Michael J.
, p. 4267 - 4272 (2007/10/03)
Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-α (TNF-α) production. Many of these compounds show low nanomolar activity against lipopolysaccaride (LPS)-induced TNF-α production in THP-1 cells. This clas
Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
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, (2008/06/13)
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the form
