spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]

Base Information

Chemical Name:spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]
CAS No.:503303-81-9
Molecular Formula:C₁₉H₁₇FN₄O₃S
Molecular Weight:400.433
Hs Code.:

Synonyms:spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]

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Chemical Property of spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]

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Technology Process of spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]

There total 7 articles about spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 503303-80-8
2-(4-fluoro-phenyl)-1-[8-(2-methylsulfanyl-pyrimidine-4-carbonyl)-1,4-dioxa-7,8-diaza-spiro[4.4]non-7-yl]-ethanone

: 503303-81-9
spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at -5 ℃;
DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 503303-81-9
spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / NaOH / CH₂Cl₂; H₂O

2.1: O₃ / CH₂Cl₂

2.2: 78 percent / DMS / CH₂Cl₂

3.1: 75 percent / 4-methylbenzenesulfonic acid / toluene / Heating

4.1: 90 percent / H₂ / Pd/C / methanol

5.1: 82 percent / NaOH / CH₂Cl₂; H₂O

6.1: 41 percent / NaH / dimethylformamide / -5 °C

With sodium hydroxide; hydrogen; sodium hydride; toluene-4-sulfonic acid; ozone; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

: 503072-26-2
2-[2-(4-fluorophenyl)acetyl]-4-oxo-pyrazolidine-1-carboxylic acid benzyl ester

: 503303-81-9
spiro[1,3-dioxolane[2',6]-2-(4-fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one]

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 4-methylbenzenesulfonic acid / toluene / Heating

2: 90 percent / H₂ / Pd/C / methanol

3: 82 percent / NaOH / CH₂Cl₂; H₂O

4: 41 percent / NaH / dimethylformamide / -5 °C

With sodium hydroxide; hydrogen; sodium hydride; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2004.06.001