50342-17-1

Basic information

• Product Name: 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%
• Synonyms: 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%;1-(5-BroMo-2-hydroxy-4-Methylphenyl)ethanone;5-Bromo-2-hydroxy-4-methylacetophenone;1-(4-bromo-2-hydroxy-5-methylphenyl)ethanone
• CAS NO: 50342-17-1
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.0706
• Mol File: 50342-17-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 86-89°C
• Boiling Point: 308.5 °C at 760 mmHg
• Flash Point: 140.4 °C
• Appearance: /
• Density: 1.508 g/cm³
• PKA: 9.72±0.23(Predicted)
• CAS DataBase Reference: 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%(50342-17-1)
• EPA Substance Registry System: 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%(50342-17-1)

Safety Data

• Hazardous Substances Data: 50342-17-1(Hazardous Substances Data)

Usage

Uses

5-Bromo-2-hydroxy-4-methylacetophenone is used in the formation of nitrobenzofurans of the benzofuran family that is known for displaying anti-microbial properties.

Preparation

Preparation by reaction of bromine on 2-hydroxy-4- methyl-acetophenone in chloroform at

Upstream product

• 817209-21-5 1-(2-amino-5-bromo-4-methyl-phenyl)-ethanone 
• 108-39-4 3-methyl-phenol 
• 14472-14-1 4-bromo-3-methylphenol 
• 22012-59-5 4-bromo-3-methylphenyl acetate 
• 6921-64-8 4'-hydroxy-2'-methylacetophenone 

Downstream Products

• 145665-74-3 4-Acetylamino-3-nitro-benzoic acid 2-acetyl-4-bromo-5-methyl-phenyl ester 
• 4478-33-5 2-Hydroxy-α,α,4-trimethylbenzyl alcohol 
• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 6022-36-2 inulavosin 
• 145666-16-6 4-Acetylamino-3-nitro-benzoic acid 4-bromo-2-(2-bromo-acetyl)-5-methyl-phenyl ester 
• 145665-96-9 N-[4-(3,6-Dibromo-7-methyl-4-oxo-4H-chromen-2-yl)-2-nitro-phenyl]-acetamide 
• 145665-85-6 N-{4-[3-(5-Bromo-2-hydroxy-4-methyl-phenyl)-3-oxo-propionyl]-2-nitro-phenyl}-acetamide 
• 127245-64-1 ethyl 2-(2-acetyl-4-bromo-5-methylphenoxy)propionate 
• 36412-16-5 ethyl 2-acetyl-4-bromo-5-methylphenoxyacetate 

Relevant articles and documents

SUBSTITUTED TRICYCLIC COMPOUNDS

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating mammals suffering from the condition of being overweight.