6022-36-2

Basic information

• Product Name: 5-methyl-2-(2,4,4,7-tetramethyl-3,4-dihydro-2H-chromen-2-yl)phenol
• Synonyms: 2'-Hydroxy-2,4,4,7,4'-pentamethylflavan; 2,4,4,4',7-Pentamethyl-2'-flavanol; 5-17-04-00566 (Beilstein Handbook Reference); BRN 0279169; IN 531; Inulavosin; NSC 44176; Phenol, 5-methyl-2-(2,4,4,7-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)-; 2'-Flavanol, 2,4,4,4',7-pentamethyl-
• CAS NO: 6022-36-2
• Molecular Formula: C₂₀H₂₄O₂
• Molecular Weight: 296.4034
• Mol File: 6022-36-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 425.7°C at 760 mmHg
• Flash Point: 181.6°C
• Density: 1.061g/cm³
• Vapor Pressure: 7.56E-08mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 5-methyl-2-(2,4,4,7-tetramethyl-3,4-dihydro-2H-chromen-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-(2,4,4,7-tetramethyl-3,4-dihydro-2H-chromen-2-yl)phenol(6022-36-2)
• EPA Substance Registry System: 5-methyl-2-(2,4,4,7-tetramethyl-3,4-dihydro-2H-chromen-2-yl)phenol(6022-36-2)

Safety Data

• Hazardous Substances Data: 6022-36-2(Hazardous Substances Data)

Usage

General Description

5-methyl-2-(2,4,4,7-tetramethyl-3,4-dihydro-2H-chromen-2-yl)phenol, also known as S-equol, is a chemical compound that belongs to the class of phenolic compounds. It is a derivative of daidzein, a compound found in soy products, and is produced in the human body by the action of gut bacteria on daidzein. S-equol has shown potential as a dietary supplement for its estrogenic properties and potential health benefits, particularly in mitigating symptoms of menopause and improving bone health. It is also being studied for its potential role in reducing the risk of certain hormone-dependent cancers. Additionally, it has been investigated for its antioxidant and anti-inflammatory properties, with potential applications in skincare and cosmetic products.

Upstream product

• 14002-90-5 4,7-dimethyl-coumarin 
• 50342-17-1 1-(5-bromo-2-hydroxy-4-methylphenyl)ethan-1-one 
• 14472-14-1 4-bromo-3-methylphenol 
• 4478-33-5 2-Hydroxy-α,α,4-trimethylbenzyl alcohol 
• 108-39-4 3-methyl-phenol 
• 67-64-1 acetone 

Downstream Products

• 89-83-8 thymol 
• 111979-15-8 inulavosin monomethyl ether 

Relevant articles and documents

Synthesis of natural product inulavosin via Ga(OTf)3-Catalyzed Hetero Diels–Alder Dimerization of salicyl alcohol derivative

Inulavosin, a natural melanogenesis inhibitor, has been synthesized smoothly from readily available and inexpensive starting materials by using a Ga(OTf)3-catalyzed room temperature hetero Diels–Alder dimerization of salicyl alcohol derivative and a regioselective phenol monobromination as the key steps.

Synthesis of flavans: One-pot synthesis of flavans from 4- methylcoumarins

4-Methylcoumarins (2), obtained by condensation of suitable phenols (1) with ethyl acetoacetate in the presence of sulfuric acid, lead directly to flavans (3) when refluxed with sodium hydroxide and ethanediol.