23346-82-9Relevant articles and documents
N-bromosuccinimide/dibromodimethylhydantoin in aqueous base: A practical method for the bromination of activated benzoic acids
Auerbach, Joseph,Weissman, Steven A.,Blacklock, Thomas J.,Angeles, Marshall R.,Hoogsteen, Karst
, p. 931 - 934 (1993)
A new bromination method employing NBS or dibromodimethylhydantoin in aqueous base is described for the synthesis of 3-bromo-2,6-dimethoxybenzoic acid (1) and other monobrominated alkoxybenzoic acids.
Access to Atropisomerically En-riched Biaryls by the Coupling of Aryllithiums with Arynes under Control by Homochiral Oxazolines
Yalcouye, Boubacar,Berthelot-Bréhier, Ana?s,Augros, David,Panossian, Armen,Choppin, Sabine,Chessé, Matthieu,Colobert, Fran?oise,Leroux, Frédéric R.
supporting information, p. 725 - 732 (2017/01/18)
We report the preparation of axially stereoenriched biphenyls by the coupling of in situ generated aryllithiums and arynes using chiral oxazoline auxiliaries. The design of the aryne precursors, the choice of oxazoline and the reaction conditions were key to accessing the desired, highly substituted, atropisomerically enriched biarylic products. In one case, the two atropo-diastereomers could be obtained in isomerically pure form by column chromatographic separation and their absolute configurations established by X-ray crystallography. The stereoselectivity of the reaction seems to be governed by subtle parameters.
A kind of acridine compounds and use thereof
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Paragraph 0041-0043, (2016/11/21)
The invention provides an acridine compound and an application thereof. The compound has a structure as shown in a general formula I described in the specification, wherein R1 is selected from H or -CO-Ph-(o,m,p) R4; R2 is selected from O or -N-Ph-(o,m,p)