503544-95-4Relevant academic research and scientific papers
New synthesis and application of 3-substituted prolinols
Chang, Meng-Yang,Chen, Chung-Yi,Tasi, Min-Ruey,Tseng, Tze-Wei,Chang, Nein-Chen
, p. 840 - 846 (2007/10/03)
Carbon skeleton of polysubstituted pyroglutamates with three contiguous asymmetric centers was built up in one base-induced coupling/cyclization reaction of α-sulfonylacetamide with 2-bromo-2-propenoates. A simple transformation to 3-substituted prolinols
New approach to N-substituted-1,2,3,6-tetrahydro-pyridine-4-carbaldehyde, a precursor for synthesizing Aricept, isoguvacine, and deethylibophyllidine
Tsai, Min-Ruei,Sun, Pei-Pei,Chang, Meng-Yang,Changa, Nein-Chen
, p. 613 - 617 (2007/10/03)
A new route towards the synthesis of N-substituted-4-formylpiperidine using N-benzyl or tryptaminylsulfonylacetamide and α,β-unsaturated ester as starting materials is described. Formal synthesis of Aricept, deethylibophyllidine, and isoguvacine, which have potential biological activities, were synthesized via this strategy.
An efficient synthesis of N-alkyl-4-substituted 3H-pyridine-2,6-dione. Synthesis of isoguvacine and MDL-11,939
Chang, Meng-Yang,Chen, Shui-Tein,Chang, Nein-Chen
, p. 2321 - 2334 (2007/10/03)
An efficient route towards the synthesis of N-alkyl-4-substituted 3H-pyridine-2,6-dione using various N-alkyl-α-sulfonylacetamides and two α,β-unsaturated esters as starting materials is described. Isoguvacine and MDL-11,939 with have potential biological activities were synthesized via this strategy.
