503551-94-8Relevant articles and documents
Attachment of a 5-nitrofuroyl moiety to spirocyclic piperidines produces non-toxic nitrofurans that are efficacious in vitro against multidrug-resistant Mycobacterium tuberculosis
Krasavin, Mikhail,Lukin, Alexei,Vedekhina, Tatiana,Manicheva, Olga,Dogonadze, Marine,Vinogradova, Tatiana,Zabolotnykh, Natalia,Rogacheva, Elizaveta,Kraeva, Liudmila,Sharoyko, Vladimir,Tennikova, Tatiana B.,Dar'in, Dmitry,Sokolovich, Evgeny
, p. 125 - 135 (2019/01/30)
A selectively antimycobacterial compound belonging to the nitrofuran class of antimicrobials has been developed via conjugation of the nitrofuran moiety to a series of spirocyclic piperidines through an amide linkage. It proved to have comparable activity against drug-sensitive (H37Rv) strain as well as multidrug-resistant, patient-derived strains of Mycobacterium tuberculosis. The compound is druglike, showed no appreciable cytotoxicity toward human retinal pigment epithelial cell line ARPE-19 in concentrations up to 100 μM and displayed low toxicity when evaluated in mice.
Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid
Lukin, Alexey,Bagnyukova, Darya,Kalinchenkova, Natalya,Zhurilo, Nikolay,Krasavin, Mikhail
supporting information, p. 3311 - 3314 (2016/07/11)
A convenient Prins cyclization of various azacycloalkanones with homoallylic alcohol was achieved in aqueous sulfuric acid. The formal four-center, three-component reaction provides a facile and flexible entry into a range of spirocyclic amino alcohols wh
