50366-20-6

Upstream product

• 90-02-8 salicylaldehyde 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 99-77-4 ethyl 4-nitrobenzoate 
• 62-23-7 4-nitro-benzoic acid 
• 89-95-2 2-methyl-benzyl alcohol 
• 619-50-1 4-nitrobenzoic acid methyl ester 

Downstream Products

• 128445-90-9 1,3-Dihydro-1-(4-nitrophenyl)isobenzofuran 
• 412351-58-7 [Ge((C₆H₄)OCHN₂CO(C₆H₄(4-NO₂)))2] 
• 1049009-41-7 2-(4-nitrobenzoyl)benzaldehyde 
• 148422-85-9 cobalt(II) 4-nitrobenzoylhydrazone complex 
• 62081-88-3 UO₂⁽²⁺⁾*CH₃COO^(1-)*C₁₄H₁₀N₃O₄^(1-)*H₂O = UO₂(CH₃COO)(C₁₄H₁₀N₃O₄)*H₂O 

Relevant academic research and scientific papers

Tetrabromomethane as an Organic Catalyst: a Kinetic Study of CBr4-Catalyzed Schiff Condensation

Tetrabromomethane functions as an organic catalyst for non-redox reactions of carbonyl species and, in particular, it enhances the aldehyde–acyl hydrazide condensation to give N-acyl hydrazones. This simple, inexpensive, and commercially available halomet

Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides

Efficient synthetic procedures for the preparation of acid hydrazines and hydrazides were developed by converting the corresponding carboxylic acid into the methyl ester catalyzed by Amberlyst-15, followed by a reaction with hydrazine monohydrate. Sulfohydrazides were prepared from the corresponding sulfonyl chlorides and hydrazine monohydrate. Both of these group of compounds were condensed with substituted salicylaldehydes using gradient concentration methods that generated a large library of hydrazone, hydrazide and sulfohydrazide analogs. Antifungal activity of the prepared analogs showed that salicylaldehyde hydrazones and hydrazides are potent inhibitors of fungal growth with little to no mammalian cell toxicity, making these analogs promising new targets for future therapeutic development.

Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes: Application to the synthesis of escitalopram

An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, o-aroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. The mild and general st

A versatile and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans

(Chemical Equation Presented) A convenient, versatile, and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans has been developed. It involves chemoselective addition of arylmagnesium reagents to the aldehyde function of o-aroylbenzaldehydes, themselves readily obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. Various functional groups, including nitro, iodo, or ester functionalities, have thus been positioned with complete regiospecificity on the 1,3-diphenylisobenzofuran backbone.

Synthesis of some novel pharmacologically active schiff bases using microwave method and their derivatives formazans by conventional method

Condensation of p-nitrobenzoylhydrazide 1 with substituted aromatic aldehydes 2 under microwave irradiation and by conventional method provide Schiff bases 3a-j. Schiff bases 3a-j on condensation with diazonium salt of 6-methoxy-2-aminobenzothiazole give formazans 4a-j. This reaction is carried out only by conventional method.