5037-63-8

Usage

Uses

Used in Pharmaceutical Industry:
5,8-Dimethyl-1-tetralone is used as a synthetic intermediate for the production of various drugs and fine chemicals. Its unique structural features and reactivity make it a valuable component in the development of pharmaceuticals.
Used in Chemical Industry:
In the chemical industry, 5,8-Dimethyl-1-tetralone serves as a key intermediate in the synthesis of a range of organic compounds, contributing to the creation of diverse chemical products.
Used in Organic Synthesis:
5,8-Dimethyl-1-tetralone is used as a building block in organic synthesis, taking advantage of its reactivity to form complex organic molecules for various applications.
Used in Medicinal Chemistry:
Due to its potential biological activity, 5,8-Dimethyl-1-tetralone is used in medicinal chemistry as a subject of research for its possible pharmacological properties, exploring its utility in the development of new therapeutic agents.

InChI:InChI=1/C12H14O/c1-8-6-7-9(2)12-10(8)4-3-5-11(12)13/h6-7H,3-5H2,1-2H3

Upstream product

• 71526-84-6 2',5'-dimethyl-4-chlorobutyrophenone 
• 930-68-7 cyclohexenone 
• 74-99-7 prop-1-yne 
• 96-48-0 4-butanolide 
• 106-42-3 para-xylene 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 32820-12-5 5,8-Dimethyl-1-tetralol 
• 80710-75-4 5,8-Dimethyl-1-p-tolyl-1,2,3,4-tetrahydro-naphthalen-1-ol 
• 85973-04-2 5,6-dihydro-7,10-dimethyl-2,4-diphenylbenzochromenylium trifluoromethanesulphonate 
• 30098-36-3 1,2,3,4-Tetrahydro-5,8-dimethyl-7-bromnaphthalin-1-on 
• 85973-17-7 5,6,8,9-tetrahydro-1,4-dimethyl-7-phenyldibenzacridine 
• 85973-16-6 5,6-dihydro-7,10-dimethyl-2,4-diphenylbenzoquinoline 
• 85973-20-2 5,6-dihydro-7,10-dimethyl-4-phenyl-2-t-butylbenzoquinoline 
• 56162-01-7 5,8-Dimethyl-4-p-tolyl-1,2-dihydro-naphthalene 
• 56162-00-6 5,8-Dimethyl-4-phenyl-1,2-dihydro-naphthalene 
• 13621-25-5 5,7-dimethyltetralone 
• 1453-06-1 4-(p-xylyl)butyric acid 
• 23702-41-2 1-Oxo-5,8-dimethyl-2-(2-isobutyrylcyclohexyl)-tetralin 
• 85990-49-4 5,6,8,9-tetrahydro-1,4-dimethyl-7-phenyldibenzoxanthylium trifluoromethanesulphonate 
• 109381-28-4 5,8-dimethyl-2-(phenylmethyl)-1-naphthol 

Relevant academic research and scientific papers

PROCESS FOR PRODUCING AROMATIC COMPOUNDS BY FRIEDEL-CRAFTS REACTION

There is provided a process for producing an aromatic compound by Friedel-Crafts reaction product, which comprises reacting an aromatic compound with an ester compound in the presence of a heteropolyacid-containing solid acid catalyst.

Alkylation-acylation of aromatics with γ-butyrolactone catalyzed by heteropolyacids supported on silica

Silica-supported H4SiW12O40 catalyzed efficiently alkylation/acylation of 1,3,5-trimethylbenzene or p-xylene with γ-butyrolactone to 4-(2,4,6-trimethylphenyl) butyric acid or to dimethyl-α-tetralone (5,8-dimethyl-3,4-dihyd

A new synthesis of occidol

Sodium borohydride reduction of 5,8-dimethyl-3,4-dihydronaphthalen-1-(2H)-one (4) yielded 5,8-dimethyl-1,2,3,4-tetrahydro-1-naphthol (5). The tetralol 5 on Vilsmeier-Haack reaction with N,N-dimethylacetamide yielded 1-(5,8-dimethyl-3,4-dihydro-2-naphthyl)

Modern Friedel-Crafts chemistry XIII. Intra- and intermolecular cyclization of some carbonyl derivatives under Friedel-Crafts conditions

Carbonyl group deactivation in the cycloalkylation of aryl haloalkyl ketones was studied.Ketones 1-5 were prepared and subjected to treatment with AlCl3, AlCl3/H2SO4 and H2SO4 catalysts.Whereas AlCl3 catalyst gave no cyclization products, the use of AlCl3/H2SO4 and H2SO4 catalysts afforded the corresponding indanones and/or tetralones (6-11).The intermediate p-methylacrylophenone (12) was also obtained in the case of ketone 2.Furthermore intermolecular cyclizations of benzene, toluene and p-xylene with 3-chloropropionyl chloride (13) and 4-chlorobutyryl chloride (14) were investigated.In the presence of AlCl3/CH3NO2 catalyst, only the corresponding aryl haloalkyl ketones (1-5) were formed whereas the use of AlCl3 catalyst gave, in addition, some cyclic ketones.However, the use of AlCl3/H2SO4 catalyst gave only the corresponding cyclic ketones (6-11).Results are discussed and mechanisms are suggested.In conclusion, carbonyl group deactivation for ring closure is demonstrated in the investigated ketones and cyclization can only effected under strenuous conditions.