50373-76-7

Upstream product

• 3457-48-5 1,2-di(4-methylphenyl)-1,2-ethanedione 
• 57-13-6 urea 
• 104-87-0 4-methyl-benzaldehyde 
• 1218-89-9 4,4'-dimethylbenzoin 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 151-50-8 potassium cyanide 
• 120-89-8 parabanic acid 
• 108-88-3 toluene 

Downstream Products

• 56079-89-1 3-[3-(4-phenyl-piperidin-1-yl)-propyl]-5,5-di-p-tolyl-imidazolidine-2,4-dione 
• 56079-97-1 3-[3-(4-hydroxy-4-phenyl-piperidin-1-yl)-propyl]-5,5-di-p-tolyl-imidazolidine-2,4-dione 
• 309253-29-0 N-diphenylmethyl-N'-[1,1-bis(4-methylphenyl)-1-(methoxycarbonyl)methyl]sulfamide 
• 309253-27-8 N-tert-butyl-N'-[1,1-bis(4-methylphenyl)-1-(methoxycarbonyl)methyl]sulfamide 
• 309253-14-3 amino-di-p-tolyl-acetic acid methyl ester 
• 309253-56-3 amino-di-p-tolyl-acetic acid 

Relevant academic research and scientific papers

Magnetic magnetite nanoparticals catalyzed selective oxidation of Α-hydroxy ketones with air and one-pot synthesis of benzilic acid and phenytoin derivatives

A clean and efficient protocol for selective oxidation of α-hydroxy ketones using magnetic magnetite nanoparticals (Fe3O4·MNPs) as catalyst with air as green oxidant has been developed. Application of Fe3O4·MNPs was also proved to be successful in one-pot synthesis of benzilic acid and phenytoin derivatives. The facile one-pot procedure enhanced the production efficiency, shortened the reaction time and minimized the chemical waste. Notably, the catalyst can be reused at least for five times without any appreciable loss of its activity.

One-pot synthesis of phenytoin analogs

A series of phenytoin analogs (5,5-diphenylimidazolidine-2,4-dione or 5,5-diphenyl-hydantoin) were synthesized in 65-75% yield from the corresponding substituted benzils. The same products were also obtained directly from α-hydroxy ketones via one-pot procedure.

An improved procedure for the synthesis of 4,4-disubstituted-3-oxo-1,2,5-thiadiazolidine 1,1-dioxides

An improved synthesis for the preparation of 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been developed. This facile two-step procedure from α-amino acid esters and chlorosulfonyl isocyanate results in excellent yields of products.

3-alkyl-(5,5'-diphenyl)imidazolidinediones as new cannabinoid receptor ligands

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.

Superacid Activated Condensation of Parabanic Acid and Derivatives with Arenes. A New Synthesis of Phenytoin and 5,5-Diarylhydantoins

A new synthetic route to phenytoin and 5,5-diarylhydantoins is repoted.Parabanic acid is converted to the 5,5-diarylhydantoins (65-98percent yield) from CF3SO3H and arenes.Deuterium substituted products are prepared in high yield from parabanic acid, CF3SO3D, and deuterated arenes.