5039-15-6

Basic information

• Product Name: N-ethyl-4-phenyl-1,3-thiazol-2-amine
• Synonyms: N-ethyl-4-phenyl-1,3-thiazol-2-amine
• CAS NO: 5039-15-6
• Molecular Weight: 204.296
• Mol File: 5039-15-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-ethyl-4-phenyl-1,3-thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-4-phenyl-1,3-thiazol-2-amine(5039-15-6)
• EPA Substance Registry System: N-ethyl-4-phenyl-1,3-thiazol-2-amine(5039-15-6)

Safety Data

• Hazardous Substances Data: 5039-15-6(Hazardous Substances Data)

Upstream product

• 625-53-6 ethyl-2-thiourea 
• 100-41-4 ethylbenzene 
• 100-42-5 styrene 
• 2010-06-2 2-Amino-4-phenylthiazole 
• 542-85-8 Ethyl isothiocyanate 
• 19433-17-1 acetophenone O-acetyloxime 
• 70-11-1 α-bromoacetophenone 
• 5039-09-8 2-acetamide-4-phenyl-1,3-thiazole 

Relevant articles and documents

Copper-Catalyzed Coupling of Oxime Acetates with Isothiocyanates: A Strategy for 2-Aminothiazoles

A new strategy for 2-aminothiazoles is developed via the copper-catalyzed coupling of oxime acetates with isothiocyanates. Various 4-substituted and 4,5-disubstituted 2-aminothiazoles were formed smoothly under mild reaction conditions. This process involved copper-catalyzed N-O bond cleavage, activation of vinyl sp2 C-H bonds, and C-S/C-N bond formations. It is noteworthy that the oxime acetates were used not only as a substrate but also as a single oxidant.

Method for synthesizing novel 2-aminothiazole ring derivatives

The invention discloses a method for synthesizing 2-aminothiazole ring derivatives and belongs to the technical field of organic synthesis. The method comprises that an ethylbenzene compound, dibromohydantoin DBH and t-butyl hydroperoxide TBHP are sequentially added to water, the solution undergoes a reaction at 60 DEG C, the reaction product is cooled, an inorganic base and a thiourea compound are orderly added into the reaction product and the mixture undergoes a reaction at 80 DEG C to produce desired product 2-aminothiazole ring derivatives. The method has the advantages of high yield, mild reaction, low cost and environmental friendliness.

Method for synthesizing 1,3-substituted thiazole ring compound by styrene compound

The invention discloses a method for synthesizing a 1,3-substituted thiazole ring compound by a styrene compound, and belongs to the technical field of synthesis of thiazole ring compounds. The method is characterized by comprising the following steps: dissolving the styrene compound and a phase transfer catalyst into water, adding dibromohydantoin DBH, carrying out a reaction at 60 DEG C, spin-drying after the reaction and dissolving into an organic solvent, adding a thiourea compound and performing reflux reaction to prepare a target product 1,3-substituted thiazole ring compound. The synthesis method provided by the invention is high in yield, mild in reaction, low in cost and environmentally friendly.