5041-97-4

Basic information

• Product Name: kaempferol 7-O-α-L-rhamnopyranoside
• Synonyms: kaempferol 7-O-α-L-rhamnopyranoside
• CAS NO: 5041-97-4
• Molecular Weight: 432.384
• Mol File: 5041-97-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: kaempferol 7-O-α-L-rhamnopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: kaempferol 7-O-α-L-rhamnopyranoside(5041-97-4)
• EPA Substance Registry System: kaempferol 7-O-α-L-rhamnopyranoside(5041-97-4)

Safety Data

• Hazardous Substances Data: 5041-97-4(Hazardous Substances Data)

Upstream product

• 482-38-2 kaempferitrin 
• 57526-56-4 kaempherol 3-O-[α-L-rhamnopyranosyl-(1->6)]-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside 
• 2392-95-2 kaempferol 3-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside 
• 89946-00-9 lepidoside 
• 129369-23-9 cassinopin 

Downstream Products

• 73-34-7 L-rhamnose 
• 520-18-3 kaempferol 
• 7658-08-4 D-quionovose 
• 3615-41-6 L-Rhamnose 
• 85561-89-3 kaempherol 7-O-α-L-rhamnoside peracetate 

Relevant articles and documents

Flavonol glycoside from humulus lupulus

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The Gastrointestinal Tract Metabolism and Pharmacological Activities of Grosvenorine, a Major and Characteristic Flavonoid in the Fruits of Siraitia grosvenorii

Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii (Swingle) C. Jeffrey, a medical plant endemic to China. In the present study, for the first time, the grosvenorine metabolism in an in vitro simulated human gastrointestinal tract (including artificial gastric juice, artificial intestinal juice and intestinal flora), as well as its pharmacological activities (including anti-complement, antibacterial and antioxidant activities), was investigated. The results showed that grosvenorine was metabolized by human intestinal flora; its four metabolites were isolated by semi-preparative HPLC and identified by NMR as kaempferitrin, afzelin, α-rhamnoisorobin, and kaempferol. Further pharmacological evaluation showed that grosvenorine exhibited good antibacterial and antioxidant activities, with its metabolites possessing more potent activities. Although grosvenorine did not present obvious anticomplement activity, its metabolites showed interesting activities. This study revealed that intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.

Changes in flavonoid content and tyrosinase inhibitory activity in kenaf leaf extract after far-infrared treatment

The tyrosinase inhibitory activity of ethanolic extract of kenaf (Hibiscus cannabinus L.) leaf was evaluated before and after subjecting it to far-infrared (FIR) irradiation. The main component of the extract was analyzed as kaempferitrin (kaempferol-3,7-O-α-dirhamnoside). Prior to FIR irradiation, no inhibitory activity of the extract was detected in a tyrosinase assay. However, after FIR irradiation for 1 h at 60 °C, significant tyrosinase inhibitory activity (IC50 = 3500 ppm) was observed in it. In HPLC analysis, derhamnosylation products (kaempferol, afzelin, and α-rhamnoisorobin) were detected. The inhibitory activity may be due to the existence of derhamnosylation products. This study demonstrated that FIR irradiation can be used as a convenient tool for deglycosylation of flavonoid glycoside.