50427-08-2

Upstream product

• 53736-37-1 2-nitroamino-4(3H)-pyrimidinone 
• 62-53-3 aniline 
• 6328-58-1 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one 
• 55996-28-6 6-methyl-2-methoxy-4(3H)-pyrimidinone 
• 141-97-9 ethyl acetoacetate 
• 6685-76-3 phenylguanidinium hydrogencarbonate 
• 2002-16-6 1-phenylguanidine 

Downstream Products

• 6967-54-0 6-methyl-2-phenylamino-4-chloropyrimidine 
• 110235-47-7 mepanipyrim 
• 1412896-90-2 4-(4-iodophenyl)amino-6-methyl-2-phenylaminopyrimidine hydrochloride 
• 53112-26-8 4-methyl-N-phenylpyrimidin-2-amine 

Relevant academic research and scientific papers

Anilinopyrimidine compound and medical use thereof

The invention relates to an anilinopyrimidine represented by general formula (I), and a pharmaceutically acceptable salt, a solvate and a prodrug thereof. Substituent groups R1, R2, R3, R4, R5, R6, R7, R8, R9, Q and n in the general formula (I) are as def

Method for preparing mepanipyrim

The invention provides a preparation method of mepanipyrim and belongs to the field of pesticide chemical synthesis technologies. The preparation method of the mepanipyrim comprises the following steps: firstly, reacting phenyl guanidine salt with ethyl acetoacetate so as to prepare phenylamino pyrimidone, reacting the phenylamino pyrimidone with phosphorus oxychloride so as to prepare 2-chloro-pyrimidine phenylamine; subsequently, carrying out coupling and crossing reaction between the 2-chloro-pyrimidine phenylamine and alkyne so as to prepare mepanipyrim. The preparation method of mepanipyrim has the advantages that the used raw materials and reagents are cheap and easily available; the reaction process is simple, the reaction conditions are mild, the cost is low, the yield is high, a good condition is created for industrial large-scale production and commercialization of the products.

Effect of the structural modification of 2-benzylamino-4-(4-iodophenyl) amino-6-methylpyrimidine on the biological activity of its derivatives

Abstract-Modification of the aliphatic-aromatic moiety in the 2-benzylmino-4-(4-iodophenyl)amino-6- methylpyrimidine leads to a change in the site of biological action of the formed structural analogs. Pleiades Publishing, Ltd., 2012.

REACTIONS WITH 6-METHYL-2-THIOURACIL SYNTHESIS OF DIPYRIMIDINOTHIAZINE. A NEW RING SYSTEM

Bromination of 6-methyl-2-thiouracil (I) gave the 5-bromo analogue II.Alkylation of each of I and II yielded the S-alkyl derivatives IIIa-g.Cyclisation of IIIa,c gave the 3,7-dimethylthiazolopyrimidines VIIa,b.The 2-arylmethylenethiazolopyri

6-ALKYL- AND 5,6-DIALKYL-2-METHOXY-4-(3H)-PYRIMIDINONES IN THE TRANSFORMATIONS OF PYRIMIDINES. CONVERSION INTO 2-SUBSTITUTED AMINO- AND 4-CHLORO-PYRIMIDINE-DERIVATIVES

6-Alkyl- and 5,6-dialkyl-2-methoxy-4(3H)-pyrimidinones are transformed into the 2-alkyl (and 2-aryl)amino-derivatives, in good yield, by reaction with the corresponding amines.Treatment with SOCl2-DMF gives 6-alkyl- and 5,6-dialkyl-2-methoxy-4-chloropyrimidines.