6967-54-0

Basic information

• Product Name: 2-Anilino-4-chloro-6-methylpyrimidine
• Synonyms: 2-Anilino-4-chloro-6-methylpyrimidine
• CAS NO: 6967-54-0
• Molecular Formula: C₁₁H₁₀ClN₃
• Molecular Weight: 219.67
• Product Categories: pharmacetical
• Mol File: 6967-54-0.mol

Chemical Properties

• Boiling Point: 383.2°C at 760 mmHg
• Flash Point: 185.5°C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 4.48E-06mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 2-Anilino-4-chloro-6-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Anilino-4-chloro-6-methylpyrimidine(6967-54-0)
• EPA Substance Registry System: 2-Anilino-4-chloro-6-methylpyrimidine(6967-54-0)

Safety Data

• Hazardous Substances Data: 6967-54-0(Hazardous Substances Data)

Usage

Chemical compound

2-Anilino-4-chloro-6-methylpyrimidine

Classification

Pyrimidine

Structure

Chlorine atom at position 4, methyl group at position 6, aniline group at position 2

Potential applications

Pharmaceutical research and drug development
Interaction with biological targets such as enzymes, receptors, and proteins
Investigating and designing new therapeutic agents for various diseases
Industrial applications in materials science or agrochemicals

InChI:InChI=1/C11H10ClN3/c1-8-7-10(12)15-11(13-8)14-9-5-3-2-4-6-9/h2-7H,1H3,(H,13,14,15)

Upstream product

• 50427-08-2 6-methyl-2-phenylaminopyrimidin-4(3H)-one 
• 2002-16-6 1-phenylguanidine 
• 50427-08-2 2-anilino-6-methyl-3H-pyrimidin-4-one 
• 6685-76-3 phenylguanidinium hydrogencarbonate 
• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 62-53-3 aniline 
• 6328-58-1 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one 

Downstream Products

• 110235-47-7 mepanipyrim 
• 1412896-90-2 4-(4-iodophenyl)amino-6-methyl-2-phenylaminopyrimidine hydrochloride 
• 53112-26-8 4-methyl-N-phenylpyrimidin-2-amine 

Relevant articles and documents

Anilinopyrimidine compound and medical use thereof

The invention relates to an anilinopyrimidine represented by general formula (I), and a pharmaceutically acceptable salt, a solvate and a prodrug thereof. Substituent groups R1, R2, R3, R4, R5, R6, R7, R8, R9, Q and n in the general formula (I) are as def

Sila-condensed ring derivative and use and electroluminescent devices thereof

The invention belongs to the technical field of application of photoelectric materials, and in particular relates to a sila-condensed ring derivative and use and electroluminescent devices thereof. Electronic transmission materials with high electron mobility characteristics are formed by bonding different aromatic groups at different sites of the sila-condensed ring derivative with a silicon-fused ring as a core or changing bridging structures. A Strong covalent bond is formed between silicon and a halogen by use of the sila-condensed ring derivative as an electron transport layer, and has astrong electron-drawing effect. The sila-seven membered ring can retain the characteristics of an aromatic ring, meanwhile a non-planar structure formed by sp3 hybridization of the silicon can effectively reduce the entire molecular plane accumulation, the sila-condensed ring derivative has a high triplet state, triplet exciton pass-back can be avoided, and the sila-condensed ring derivative is suitable for fluorescence emitting and phosphorescent light emitting systems.

Method for preparing mepanipyrim

The invention provides a preparation method of mepanipyrim and belongs to the field of pesticide chemical synthesis technologies. The preparation method of the mepanipyrim comprises the following steps: firstly, reacting phenyl guanidine salt with ethyl acetoacetate so as to prepare phenylamino pyrimidone, reacting the phenylamino pyrimidone with phosphorus oxychloride so as to prepare 2-chloro-pyrimidine phenylamine; subsequently, carrying out coupling and crossing reaction between the 2-chloro-pyrimidine phenylamine and alkyne so as to prepare mepanipyrim. The preparation method of mepanipyrim has the advantages that the used raw materials and reagents are cheap and easily available; the reaction process is simple, the reaction conditions are mild, the cost is low, the yield is high, a good condition is created for industrial large-scale production and commercialization of the products.

Synthesis, antimalarial activity, heme binding and docking studies of 4-aminoquinoline-pyrimidine based molecular hybrids

A series of novel 4-aminoquinoline-pyrimidine hybrids was synthesized and evaluated for their antimalarial activity. Several compounds showed potent antimalarial activity against both CQ-sensitive and CQ-resistant strains of P. falciparum with no cytotoxi

Effect of the structural modification of 2-benzylamino-4-(4-iodophenyl) amino-6-methylpyrimidine on the biological activity of its derivatives

Abstract-Modification of the aliphatic-aromatic moiety in the 2-benzylmino-4-(4-iodophenyl)amino-6- methylpyrimidine leads to a change in the site of biological action of the formed structural analogs. Pleiades Publishing, Ltd., 2012.