50427-83-3

Basic information

• Product Name: 5-amino-3-ethyl-1-phenyl-1H-pyrazole-4-carbonitrile
• Synonyms: 5-amino-3-ethyl-1-phenyl-1H-pyrazole-4-carbonitrile;5-amino-3-ethyl-1-phenyl-4-pyrazolecarbonitrile;5-amino-3-ethyl-1-phenyl-pyrazole-4-carbonitrile;5-amino-3-ethyl-1-phenylpyrazole-4-carbonitrile;AG-826/13532003;MLS000700325;SMR000226386;ZINC00478268
• CAS NO: 50427-83-3
• Molecular Formula: C₁₂H₁₂N₄
• Molecular Weight: 212.25048
• Mol File: 50427-83-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-amino-3-ethyl-1-phenyl-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-3-ethyl-1-phenyl-1H-pyrazole-4-carbonitrile(50427-83-3)
• EPA Substance Registry System: 5-amino-3-ethyl-1-phenyl-1H-pyrazole-4-carbonitrile(50427-83-3)

Safety Data

• Hazardous Substances Data: 50427-83-3(Hazardous Substances Data)

Upstream product

• 35260-96-9 2-(1-ethoxypropylidene)malononitrile 
• 100-63-0 phenylhydrazine 
• 109-77-3 malononitrile 
• 115-80-0 Triethyl orthopropionate 

Downstream Products

• 1298095-80-3 3-ethyl-1-phenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dithione 
• 1298095-86-9 5-ethyl-2-(4-methoxyphenyl)-7-phenyl-2-thioxo-1,2,3,7-tetrahydropyrazolo[3,4-d][1,3,2]diazaphosphinine-4-thione 
• 1115445-25-4 2-chloromethyl-9-ethyl-7-phenylpyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine 
• 1448812-35-8 N-(3-chloro-5-(((4-cyano-3-ethyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1392104-03-8 6-(4-chlorophenyl)-3-ethyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 138134-20-0 3-ethyl-1-phenylpyrazole-4-carbonitrile 

Relevant articles and documents

The pyrazole derivative or its salt in a pharmaceutical composition containing them

PROBLEM TO BE SOLVED: To provide a novel compound and a pharmaceutical composition useful for treatment and/or prevention of HIV virus infections.SOLUTION: Provided is a pyrazole derivative represented by the general formula (I) or a salt thereof (in the

Synthesis of aminocyanopyrazoles via a multi-component reaction and anti-carbonic anhydrase inhibitory activity of their sulfamide derivatives against cytosolic and transmembrane isoforms

A convenient protocol for the multicomponent reaction (MCRs) between malononitrile with an orthoester and hydrazine derivatives, under acid catalyst is described. A series of aminocyanopyrazoles 4 was prepared, isolated and characterized. These pyrazoles reacted with sodium nitrite followed by secondary amine reagent and with formic acid to lead pyrazolotriazines 6 and pyrazolopyrimidinones 7. Some of the aminopyrazoles were converted to the corresponding sulfamides by reaction with sulfamoyl chloride. The aminopyrazoles incorporating phenyl and tosyl moieties were tested as inhibitors of four carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the human (h) hCA I, II, IX and XII. Many of them showed low micromolar or submicromolar inhibition of these enzymes. The corresponding sulfamides were low nanomolar CA inhibitors.