50481-48-6

Usage

Uses

Used in Pharmaceutical Research:
2-(2-Chlorophenyl)propan-2-amine hydrochloride is used as a research chemical for studying its psychoactive effects on the central nervous system. It aids in understanding its potential as a stimulant or treatment for certain medical conditions.
Used in Synthesis of Other Pharmaceuticals:
As a starting material, 2-(2-Chlorophenyl)propan-2-amine hydrochloride is utilized in the synthesis of other pharmaceuticals, contributing to the development of new medications with potential therapeutic benefits.
Used in Laboratory Settings:
2-(2-Chlorophenyl)propan-2-amine hydrochloride, in its hydrochloride salt form, is used for its improved solubility and bioavailability. This makes it easier to handle and dose in laboratory settings, enhancing the efficiency of research and experimentation.

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 3670-15-3 2-(2-chlorophenyl)propan-2-ol 
• 736055-28-0 [1-(2-chlorophenyl)-1-methyl-ethyl]-carbamic acid ethyl ester 
• 69849-08-7 2-(2-chlorophenyl)-2-methylpropanenitrile 
• 103753-46-4 2-chloro-α,α-dimethylbenzenemethanamide 
• 64946-66-3 1-Chloro-2-(1-isocyanato-1-methyl-ethyl)-benzene 

Relevant academic research and scientific papers

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

10A-AZALIDE COMPOUND HAVING 4-MEMBERED RING STRUCTURE

A 10a-azalide compound having a 4-membered ring structure crosslinked at the 10a- and 12-positions, which is represented by the formula (I), and is effective on even Haemophilus influenzae, or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA

Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders and processes for preparing these compounds.

Copper(I)-assisted mild and convenient synthesis of new Se-N heterocycles: Access to a promising class of GPx mimics

Benzisoselenazolines 15 and benzisoselenazines 21, designed as low molecular weight mimics of glutathione peroxidases, were synthesized for the first time. Starting from amines 13 and 14, a smooth introduction of selenium in nonactivated aryl bromides using KSeCN in the presence of CuI was developed. An equimolar quantity of CuI and the presence of Et3N as a base are necessary to achieve a complete conversion of the starting material. The reaction is feasible in various solvents such as DMF, acetonitrile, and THF. The desired new Se-N heterocycles 15 and 21 were isolated under optimized conditions in yields of 82 and 68%, respectively. Experiments have been conducted with various copper(I) and copper(II) salts, a chloroamine 17, an aryl bromide 18, and an N-acylated amine 19 to show the scope and the limitations of this method. The previously unknown sulfur analogues 20 and 22 have been synthesized in moderate yields using a slightly modified procedure. Finally, a mechanistic scheme has been proposed to discuss some interesting findings, which were obtained during the optimization process of this new introduction of selenium.

Synthesis and Herbicidal Activities of 1,2-Benzisoxazole-3-acetamide Derivatives

Many 1,2-benzisoxazole-3-acetamides were synthesized and their herbicidal activities in the paddy field were studied.Of the compounds tested, N-α,α-dimethylbenzyl-2-bromo-(1,2-benzisoxazol-3-yl)acetamide 10a was the most effective.Details of the synthesis and the results of herbicidal evaluations are given.