3670-15-3

Basic information

• Product Name: 2-(2-CHLOROPHENYL)PROPAN-2-OL
• Synonyms: 2-(2-CHLOROPHENYL)PROPAN-2-OL
• CAS NO: 3670-15-3
• Molecular Formula: C₉H₁₁ClO
• Molecular Weight: 170.638
• Mol File: 3670-15-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 23.7 °C
• Boiling Point: 94 °C(Press: 8 Torr)
• Appearance: /
• Density: 1.144±0.06 g/cm3(Predicted)
• PKA: 14.12±0.29(Predicted)
• CAS DataBase Reference: 2-(2-CHLOROPHENYL)PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLOROPHENYL)PROPAN-2-OL(3670-15-3)
• EPA Substance Registry System: 2-(2-CHLOROPHENYL)PROPAN-2-OL(3670-15-3)

Safety Data

• Hazardous Substances Data: 3670-15-3(Hazardous Substances Data)

Usage

Classification

Derivative of phenethylamine
It belongs to a group of chemical compounds derived from phenethylamine.

Use

Medication and antihistamine
It is primarily used as a medication to relieve allergy symptoms by acting as an antihistamine.

Symptom relief

Sneezing, itching, and watery eyes
The specific symptoms that chlorpheniramine helps alleviate are sneezing, itching, and watery eyes.

Mechanism

Blocks the action of histamine
It works by inhibiting the effects of histamine, a substance in the body responsible for causing allergic symptoms.

Availability

Over-the-counter cold and allergy medications
Chlorpheniramine can be found in many over-the-counter medications designed to treat cold and allergy symptoms.

Additional uses

Treats hives, itching, and insect bites
Apart from its primary use, chlorpheniramine can also be used to treat hives, itching, and insect bites.

Side effect

Drowsiness
One of the side effects of taking chlorpheniramine is drowsiness, which may cause impaired alertness.

Precaution

Avoid driving or operating heavy machinery
Due to the potential for drowsiness, it is recommended to avoid driving or operating heavy machinery while taking this medication.

Upstream product

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• 7335-25-3 ethyl 2-chlorobenzoate 
• 609-65-4 o-chlorobenzoyl chloride 
• 15842-76-9 (2-chloro-phenyl)-trimethyl-silane 
• 67-64-1 acetone 
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Downstream Products

• 3609-45-8 1-chloro-2-(prop-1-en-2-yl)benzene 
• 64946-66-3 1-Chloro-2-(1-isocyanato-1-methyl-ethyl)-benzene 
• 82466-13-5 2-chlorocumyl acetate 
• 26106-09-2 Benzyl-<1-(2-chlorophenyl)-1-methylethyl>-sulfid 
• 854649-68-6 2-(2-chloro-phenyl)-2-phenyl-propane 
• 739-45-7 9,9-dimethyl-10-phenyl-9,10-dihydro-anthracene 
• 855290-80-1 2-(1-methyl-1-phenyl-ethyl)-benzonitrile 
• 217-59-4 triphenylene 
• 21190-34-1 (2-isopropylphenyl)methanol 
• 180092-32-4 [2-(1-methylethenyl)phenyl]methyl alcohol 
• 15582-48-6 o-1-menthene 
• 15582-49-7 o-2-menthene 
• 3425-72-7 cumyl acetate 
• 99846-68-1 1-chloro-2-(α-chloro-isopropyl)-benzene 

Relevant articles and documents

Stepwise benzylic oxygenation via uranyl-photocatalysis

Stepwise oxygenation at the benzylic position (1°, 2°, 3°) of aromatic molecules was comprehensively established under ambient conditions via uranyl photocatalysis to produce carboxylic acids, ketones, and alcohols, respectively. The accuracy of the stepwise oxygenation was ensured by the tunability of catalytic activity in uranyl photocatalysis, which was adjusted by solvents and additives demonstrated through Stern–Volmer analysis. Hydrogen atom transfer between the benzylic position and the uranyl catalyst facilitated oxygenation, further confirmed by kinetic studies. Considerably improved efficiency of flow operation demonstrated the potential for industrial synthetic application.

Compounds of the menthane series. Synthesis of unsaturated primary alcohols with the o- and p-menthane skeletons

Precursors to terpene alcohols of the o- and p-menthane series (o-cimen-7-ol and o- and p-cimen-9-ols) were synthesized, and their reduction with lithium in ethylenediamine was studied. The reduction of o- and p-cimen-9-ols in the presence of isopropyl alcohol selectively afforded the corresponding 1,4-dihydro derivatives. Under analogous conditions, o-cimen-7-ol was converted into a mixture of unsaturated hydrocarbons. The reduction with lithium in ethylenediamine in the absence of isopropyl alcohol in all cases gave mixtures of menthene alcohols.

Palladium-catalyzed annulation of o-iodobiphenyls with o-bromobenzyl alcohols: Synthesis of functionalized triphenylenes via C-C and C-H bond cleavages

Treatment of o-iodobiphenyls with o-bromobenzyl alcohols in the presence of cesium carbonate under palladium catalysis affords a series of highly substituted triphenylenes. The reaction involves two C-C bond formations and C-C and C-H bond cleavages. A combination of palladium and an electron-deficient phosphine ligand proves to be effective for both decarbonylative cross-coupling and intramolecular cyclization.