5050-58-8

Upstream product

• 20515-62-2 2,2-dimethyloxazolidine 
• 463-51-4 Ketene 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 141-43-5 ethanolamine 
• 67-64-1 acetone 

Downstream Products

• 107557-37-9 3-Acetyl-4-tert-butoxy-2,2-dimethyloxazolidin 
• 107557-36-8 3-Acetyl-4-(benzoyloxy)-2,2-dimethyloxazolidin 
• 107557-34-6 3-Acetyl-5-(benzoyloxy)-2,2-dimethoxazolidin 
• 107574-56-1 3-Acetyl-4,5-bis(benzoyloxy)-2,2-dimethyloxazolidin 
• 107557-35-7 3-Acetyl-2,3-dihydro-2,2-dimethyloxazol 
• 107557-46-0 3-Acetyl-5-(hydroxydiphenylmethyl)-2,2-dimethyl-4-methoxyoxazolidin 
• 107557-42-6 4-Acetyl-3,3-dimethyl-7,7-diphenyl-2,6-dioxa-4-azabicyclo<3.2.0>heptan 
• 107557-45-9 3-Acetyl-5-(1-hydroxy-1-phenylethyl)-4-methoxy-2,2-dimethyloxazolidin 
• 107557-40-4 4-Acetyl-3,3,7-trimethyl-7-endo-phenyl-2,6-dioxa-4-azabicycl<3.2.0>heptan 
• 38207-11-3 1-Acetyl-2-methylpyrrol 

Relevant academic research and scientific papers

An investigation of the rotational isomers of N-acetyl-2,2-dimethyloxazolidine and related compounds by nuclear magnetic resonance spectroscopy and molecular mechanics

The 15 2,2-dimethyloxazolidines described here were found to exist in solution predominantly as a single rotational isomer, unlike N-acetyloxazolidine (1), N-acetyl-2-methyloxazolidine (2), N-acetyl-2-(n-octyl)oxazolidine (3), and other known 2-substituted N-acyloxazolidines.Using 13C NMR spectroscopy, activation energies for interconversion of the E (minor) and Z (major) rotational isomers of 1-3 were determined from coalescence temperature measurements in pyridine-d5.A sample of N-acetyl-2,2-dimethyloxazolidine (4) was isolated for comparison.The rotational isomer of 4 was found by two-dimensional nuclear Overhauser effect spectroscopy (NOESY) to possess the Z (or trans) stereochemistry.Molecular mechanics (MMX) calculations on the E and Z isomers of 1-4 helped to account for these findings.The conformation of the energy-minimized structures resemble a C-5 envelope.Samples of N-aroyl-2,2-dimethyloxazolidines (5a-5n) were isolated and the rotational isomers were assigned the Z stereochemistry by NOESY and 13C NMR experiments.Most of these 2,2-dimethyloxazolidines were ineffective in a bioassay for mosquito repellent activity. Key words: N-acyloxazolidines, N-aroyloxazolidines, NMR spectroscopy, rotational isomerism, molecular mechanics.

3-Acetyl-2,3-dihydro-2,2-dimethyloxazole; Synthesis, Properties and Its Application as Olefinic Partner in the Paterno-Buechi Reaction

The preparation and properties of 3-acetyl-2,3-dihydro-2,2-dimethyloxazole (3) are described.The compound rearranges to 1-acetyl-2-methylpyrrole (8) on pyrolysis in presence of protons. 3 reacts with acetone and benzophenone photochemically under formation of both regioisomeric oxetanes 9,10 and 12, 13.The regioisomer 11 is the selective product in the case of acetophenone.