505068-89-3Relevant academic research and scientific papers
Synthesis of optically active 2,2-difluorohomoallylalcohols by lipase-catalyzed transesterification
Kirihara, Masayuki,Kawasaki, Masashi,Katsumata, Hiroki,Kakuda, Hiroko,Shiro, Motoo,Kawabata, Shigeki
, p. 2283 - 2289 (2002)
Racemic 2,2-difluorohomoallylalcohols could be resolved into (R)-alcohols and (S)-acetates through Pseudomonas fluorescens lipase-catalyzed enantioselective transesterification. The utility of the resulting chiral, non-racemic 2,2-difluorohomoallylalcohol
Vinylation of Iododifluoromethylated Alcohols via a Light-Promoted Intramolecular Atom-Transfer Reaction
Panferova, Liubov I.,Struchkova, Marina I.,Dilman, Alexander D.
, p. 4124 - 4132 (2017/09/12)
A method for the synthesis of gem -difluorohomoallylic alcohols by the substitution of iodine in the iododifluoromethyl group by a vinyl fragment is described. The reaction proceeds via an intramolecular iodine atom transfer followed by β-elimination. The reaction is performed in the presence of an iridium photocatalyst, fac -Ir(ppy) 3, and triphenylphosphine under irradiation with light-emitting diodes.
