5051-47-8

Basic information

• Product Name: 2-(2-chlorobenzylidene)-1,1-dimethylhydrazine
• CAS NO: 5051-47-8
• Molecular Formula: C₉H₁₁ClN₂
• Molecular Weight: 182.65
• Mol File: 5051-47-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 290°C at 760 mmHg
• Flash Point: 129.2°C
• Density: 1.06g/cm³
• Vapor Pressure: 0.00212mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: 2-(2-chlorobenzylidene)-1,1-dimethylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorobenzylidene)-1,1-dimethylhydrazine(5051-47-8)
• EPA Substance Registry System: 2-(2-chlorobenzylidene)-1,1-dimethylhydrazine(5051-47-8)

Safety Data

• Hazardous Substances Data: 5051-47-8(Hazardous Substances Data)

Usage

Compound type

Hydrazine derivative

Key functional group

Chlorobenzylidene group

Backbone structure

1,1-dimethylhydrazine

Primary use

Synthesis of pharmaceutical drugs

Utility in

Medicinal and chemical applications

Potential use

Building block for synthesizing other compounds, research and development

Safety

Proper handling and precautions required

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 57-14-7 N,N-Dimethylhydrazine 

Downstream Products

• 111269-61-5 1-(2-Chloro-phenyl)-3,3,3-trifluoro-propane-1,2-dione 
• 719-54-0 10-methyl-9, 10-dihydro-9-acridinone 
• 873-32-5 2-Chlorobenzonitrile 
• 111269-41-1 3-(2-Chloro-phenyl)-3-(dimethyl-hydrazono)-1,1,1-trifluoro-propan-2-one 
• 52372-78-8 2-chlorobenzaldehyde hydrazone 

Relevant articles and documents

Synthesis of o -(dimethylamino)aryl ketones, acridones, acridinium salts, and 1 H -indazoles by the reaction of hydrazones and arynes

A novel, efficient route to biologically and pharmaceutically important o-(dimethylamino)aryl ketones, acridones, acridinium salts, and 1H-indazoles has been developed starting from readily available hydrazones of aldehydes and o-(trimethylsilyl)aryl triflates. The reaction proceeds through arynes under mild conditions, tolerates a wide range of functional groups, and provides the final products in good to excellent yields.

Synthesis of β-lactams via cycloaddition of hydrazones with phenoxyketene

Phenoxyketene is capable of annelating the disubstituted hydrazones to afford stereoselectivity cis-monocyclic β-lactams with a 1-amino functionality. The ease of cycloaddition is governed by substitutents on the azomethine carbon as well as on the hydraz