50552-44-8Relevant academic research and scientific papers
Umpolung Reactions of α-Tosyloximino Esters in a Flow System
Ota, Kazuki,Fukumoto, Shinya,Iwase, Taiki,Mizota, Isao,Shimizu, Makoto,Hachiya, Iwao
supporting information, p. 1930 - 1936 (2020/09/18)
An umpolung reaction of α-tosyloximino esters in a flow system is disclosed. Tandem N, N-dialkylations with two different Grignard reagents gave the desired N, N-dialkylated products in moderate to good yields. In addition, a tandem N, N, C-trialkylation of an α-tosyloximino ester with three different Grignard reagents has been successfully achieved to afford the desired N, N, C-trialkylated product in moderate yield.
N,N-Di- and N,N,C-Trialkylation of δ-sulfoximino esters
Hata, Shingo,Maeda, Tatsuya,Shimizu, Makoto
supporting information, p. 1203 - 1205 (2013/01/15)
N,N-Dialkylation of α-sulfoximino esters with Grignard reagents proceeds to give α-N,N-dialkylamino esters. N,N,CTrialkylated product is also obtained via the oxidation and nucleophilic addition reaction of the intermediary enolate.
