50591-21-4

Usage

Class

Benzimidazoles (heterocyclic compounds containing a benzene ring fused to an imidazole ring)

Substituent

Ethoxy group (C2H5O) attached to the fifth position of the benzimidazole ring

Biological and pharmacological properties

Potential use as anti-parasitic, anti-cancer, and anti-inflammatory agents

Importance of ethoxy group

May impart specific chemical and pharmacological properties to the compound

Research and development potential

Interesting target for further research and development in the pharmaceutical and medicinal chemistry fields.

Upstream product

• 885-81-4 N-(4-ethoxy-2-nitrophenyl)acetamide 
• 67169-91-9 N-(2-amino-4-ethoxyphenyl)acetamide 
• 62-44-2 4-ethoxyacetanilide 
• 64-18-6 formic acid 
• 1197-37-1 4-ethoxy-benzene-1,2-diamine 

Downstream Products

• 41292-65-3 5-hydroxy-1H-benzimidazole 

Relevant academic research and scientific papers

Physico-chemical activity relationship of some substituted benzimidazoles

2-Alkyl-(5 or 6)-ethoxybenzimidazoles were prepared by Phillip's condensation procedure. Their analgesic potency, CNS depessant activity and antifungal activity were founded. An attempt was made to correlate the biological activities with physicochemical constants like partition co- efficient and pka values of the compounds synthesised. Hansch constant (π) of the test compounds were found to have linear correlation with CNS depressant activity, while pka values showed a near linear relationship with analgesic potency.

Inhibition of Rat Hepatic Microsomal Aminopyrine N-Demethylase Activity by Benzimidazole Derivatives. Quantitative Structure-Activity Relationships

Eighty-two benzimidazole derivatives have been prepared and tested for the ability to inhibit cytochrome P-450 mediated enzyme activity (aminopyrine N-demethylase) from phenobarbitone-induced rat hepatic microsomes.Using physicochemical parameters and multiple regression analysis, we derived a quantitative structure-activity relationship (QSAR) that describes up to 87percent of the data variance in terms of hydrophobic and electronic effects and the molar refractivity of the substituent in the 2-position of the benzimidazole ring.