50591-24-7

Upstream product

• 64-19-7 acetic acid 
• 3360-78-9 4-methoxy-N-methyl-1,2-phenylenediamine 
• 4887-81-4 6-methoxy-2-methyl-1H-benzo[d]imidazole 
• 74-88-4 methyl iodide 
• 444995-66-8 N-(2-bromo-5-methoxy-phenyl)-thioacetamide 
• 123027-99-6 N-(2-bromo-5-methoxyphenyl)ethanamide 
• 59557-92-5 2-bromo-5-methoxyaniline 
• 444995-74-8 N-(2-bromo-5-methoxy-phenyl)-N'-methyl-acetamidine 

Relevant academic research and scientific papers

PROBES FOR IMAGING HUNTINGTIN PROTEIN

Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. Formula (I)

An improved procedure for the synthesis of benzimidazoles, using palladium-catalyzed aryl-amination chemistry

New, improved conditions have been developed and optimized for the synthesis of benzimidazoles by intramolecular palladium-catalyzed aryl-amination chemistry. This methodology, combined with a catch and release purification strategy, has led to a range of these heterocycles being prepared rapidly and in excellent yield.

An intramolecular palladium-catalysed aryl amination reaction to produce benzimidazoles

A novel synthesis of benzimidazoles by a palladium-catalysed intramolecular N-arylation reaction from (o-bromophenyl)amidine precursors is described.