50591-78-1Relevant academic research and scientific papers
Reductive Amination Revisited: Reduction of Aldimines with Trichlorosilane Catalyzed by Dimethylformamide─Functional Group Tolerance, Scope, and Limitations
Campbell, Joanna L. P.,Davies, Christopher D.,Ho?ek, Jan,Ko?ovsky, Pavel,Kysilka, Ond?ej,Popov, Kirill K.,Pour, Milan
, p. 920 - 943 (2022/01/27)
Aldimines, generated in situ from aliphatic, aromatic, and heteroaromatic aldehydes and aliphatic, aromatic, and heteroaromatic primary or secondary amines, can be reduced with trichlorosilane in the presence of dimethylformamide (DMF) as an organocatalys
Certain acylamino-oxa (or thia) diazoles in treatment of hypersensitivity conditions
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, (2008/06/13)
Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the compounds. The compounds have anti-allergy activity.
Mesoionic purinone analogs. 7. In vitro antibacterial activity of mesoionic 1,3,4 thiadiazolo[3,2 a]pyrimidine 5,7 diones
Coburn,Glennon,Chmielewicz
, p. 1025 - 1027 (2007/10/04)
The discovery of in vitro antibacterial activity of mesoionic thiazolo[3,2-αDpyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-α]pyrimidine-5,7-diones has been recently reported. These compounds are members of a large, virtually unknown, class of mesoionic structures, termed mesoionic purinone analogs, which are isoelectronic and isosteric to the purinones: xanthine, hypoxanthine, or purin-2-one. The formulation, classification, and quantum chemical study of a large number of these heterocyclic structures have been described. A series of alkyl and aryl substituted mesoionic 1,3,4-thiadiazolo[3,2-α]pyrimidine-5,7-diones, mesoionic xanthine analogs, was prepared and examined for antibacterial activity in order to develop structure activity relationships leading to more active derivatives.
