50605-47-5

Upstream product

• 67-56-1 methanol 
• 6367-08-4 N²-acetyl-N⁶-[(benzyloxy)carbonyl]-L-lysine 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 
• 108-24-7 acetic anhydride 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 75-77-4 chloro-trimethyl-silane 
• 186581-53-3 diazomethane 

Downstream Products

• 6072-02-2 N-acetyl-L-lysine methyl ester 

Relevant academic research and scientific papers

Ditopic crown ether-guanidinium ion receptors for the molecular recognition of amino acids and small peptides

A series of ditopic synthetic receptors based on a crown ether-guanidinium ion recognition motif is reported. The compounds show binding affinity to selected amino acids, including important neurotransmitters. The effect of the distance of the ammonium and the carboxylate ion, the rigidity of the spacer, and the use of pre-organized pyrrole- and pyrene-guanidinium groups on binding affinity and selectivity are discussed.

Peptide-bond Formation, Chemoselective Acylation of Amino Acids, and Crosslinking Reaction between Amino Acids Utilizing a Functional Five-membered Heterocycle, 1,3-Thiazolidine-2-thione

The monitored aminolysis of 3-acyl-1,3-thiazolidine-2-thiones has been extended to the peptide-bond formation, the chemoselective acylation of amino acids having multifunctional groups, and the crosslinking reaction between amino acids.

MONITORED AMINOLYSIS OF 3-ACYL-1,3-THIAZOLIDINE-2-THIONE WITH AMINO ACID AND ITS DERIVATIVE: PEPTIDE BOND FORMATION, CHEMOSELECTIVE ACYLATION, AND BRIDGING REACTION

As a new extention of the monitored aminolysis of 3-acyl-1,3-thiazolidine-2-thione, its applications to peptide bond formation, chemoselective acylation of amino acid, and bridging reaction on the enzyme model are reported.