50609-00-2

Upstream product

• 50609-01-3 4-(2-pyrrolidinoethoxy)aniline 
• 463-71-8 thiophosgene 
• 7250-67-1 1-(2-chloroethyl)pyrrolidine hydrochloride 
• 123-30-8 4-amino-phenol 
• 75-15-0 carbon disulfide 
• 541-41-3 chloroformic acid ethyl ester 
• 102368-13-8 1,1'-Thiocarbonyldi-2(1H)-pyridone 

Downstream Products

• 852045-99-9 [4-(2-pyrrolidin-1-ylethoxy)phenyl]thiourea 
• 852045-46-6 Flt-3 Inhibitor III 
• 852046-11-8 3-methylsulfanyl-1-phenyl-3-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-propenone 
• 38519-94-7 (5-methoxy-benzothiazol-2-yl)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine 
• 1035994-38-7 5-(6,7-dimethoxyquinazolin-4-yl)-N₂-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thiazole-2,4-diamine 
• 627462-77-5 [4-amino-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone acetate 

Relevant academic research and scientific papers

DIAMINOTHIAZOLES USEFUL AS AXL INHIBITORS

Diaminothiazoles and pharmaceutical compositions containing them are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the diaminothiazoles in treating diseases or conditions associated with Axl activity are also disclosed.

Aromatic interactions with phenylalanine 691 and cysteine 828: A concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents

FLT3 kinase inhibitors are currently under investigation as a new treatment for acute myeloid leukemia. We report here a molecular concept invoking interactions between an aromatic ring and the side chains of Phe691 and Cys828, two residues of the ATP poc

THIAZOLE AND PYRAZOLE DERIVATIVES AS FLT-3 KINASE INHIBITORS

The invention relates to thiazole and pyrazole derivatives of formula (I) wherein Q is S and X is C, or Q is CH and X is N; R1 is unsubtituted or substituted phenyl; and R2 is unsubstituted or substituted aryl or heteroaryl; oa a salt of the said compounds, and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour disease, in particular such diseases which respond to an inhibition of the FIt-3 kinase.

DIAMINOTHIAZOLES

The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment 6r control of breast, lung and colon and prostate tumors.

Anilinobenzothiazoles as antidepressants

New anilinobenzothiazoles are used for treating depression.