50616-86-9

Upstream product

• 78470-95-8 6,7-dichloroquinoxaline-2(1H)-one 
• 100-63-0 phenylhydrazine 
• 2339-78-8 1,2-dichloro-4-fluoro-5-nitrobenzene 
• 90793-48-9 N-(4,5-Dichlor-2-nitro-phenyl)-glycin-ethylester 
• 153505-40-9 6,7-Dichloro-3,4-dihydroquinoxalin-2(1H)-one 
• 780-69-8 triethoxyphenylsilane 
• 94-36-0 dibenzoyl peroxide 
• 98-80-6 phenylboronic acid 
• 1503-80-6 6,7-dichloro-3-phenylquinoxalin-2(1H)-one 
• 74-88-4 methyl iodide 

Downstream Products

• 1429933-87-8 (S)-6,7-dichloro-1-methyl-3-phenyl-3,4-dihydroquinoxalin-2(1H)-one 

Relevant academic research and scientific papers

Direct C-H arylation of quinoxalinones with aryl acylperoxides under catalyst-free condition

A simple and novel method for the direct C-H arylation of quinoxalinones with aryl acylperoxides has been developed. This reaction proceeded smoothly through a radical process under catalyst-free condition, giving the target products in moderate good yields. Such strategy provides a simple and green alternative for the synthesis of 3-arylquinoxalinones.

Aryl acyl peroxides for visible-light induced decarboxylative arylation of quinoxalin-2(1: H)-ones under additive-, metal catalyst-, and external photosensitizer-free and ambient conditions

Aryl radicals were generated for the first time from cheap and easily available aryl acyl peroxides in eco-friendly ethyl acetate under ambient conditions and visible-light illumination in the absence of any additive, metal catalyst, or external photosensitizer. The present arylation of quinoxalin-2(1H)-ones was chemo- and regioselective, and provided good access to various 3-arylquinoxalin-2(1H)-ones. This journal is

Visible-light-induced C[sbnd]H arylation of quinoxalin-2(1H)-ones in H2O

An efficient visible-light-induced C[sbnd]H arylation of quinoxalin-2(1H)-ones in H2O is developed, which has the advantages of mild reaction conditions, environmental friendliness and good functional group tolerance. This strategy provides a s

K2S2O8 mediated C-3 arylation of quinoxalin-2(1H)-ones under metal-, photocatalyst- And light-free conditions

Two facile and effective C-3 arylation protocols of quinoxalin-2(1H)-ones with arylhydrazines and aryl boronic acids respectively via free radical cross-coupling reactions under metal-, photocatalyst- and light-free conditions have been unveiled. K2

Palladium-catalyzed direct Hiyama arylation of quinoxalin-2(1H)-ones with aryl siloxanes in water

An efficient method for palladium-catalyzed direct Hiyama coupling of various quinoxalin-2(1H)-ones with aryl siloxanes has been developed. The protocol provides a convenient access to a variety of useful C3-arylated 1-methylquinoxalin-2(1H)-one derivatives in reasonable yields by using low cost water as a solvent and oxygen as an oxidant.

Synthetic method of 3-arylquinoxalin-2(1H)-one derivatives

The present invention relates to a method for manufacturing quinoxalin-2(1H)-one derivatives in which an aryl group is substituted at position 3 by conducting a reaction of an aryl diazonium salt from quinoxalin-2(1H)-one derivatives by using a visible li

Transition-Metal-Free Direct C-H Arylation of Quinoxalin-2(1H)-ones with Diaryliodonium Salts at Room Temperature

A method of synthesizing 3-arylquinoxalin-2(1H)-ones using diaryliodonium tetrafluoroborates under mild conditions is described. This protocol has a wide substrate scope and enables direct C-H functionalization. The synthetic potential of this coupling was explored using a range of readily accessible diaryliodonium salts and quinoxalin-2(1H)-ones.

Transition Metal-Free Iodosobenzene-Promoted Direct Oxidative 3-Arylation of Quinoxalin-2(H)-ones with Arylhydrazines

A transition metal-free iodosobenzene-promoted direct oxidative 3-arylation of quinoxalin-2(H)-ones was developed using various arylhydrazines under air. The protocol affords a variety of 3-arylquinoxalin-2(H)-one derivatives in moderate to good yields. This method provides a rapid access to biologically interesting benzo[g]quinoxalinones and pyrido[3,4-b]pyrazinones. The present methodology features high functional group tolerance including base-sensitive groups as well as allyl- and benzyl-substituted quinoxalin-2(H)-ones under mild reaction conditions. (Figure presented.).

Palladium(II)-catalyzed oxidative arylation of quinoxalin-2(1 H)-ones with arylboronic acids

A straightforward palladium-catalyzed oxidative C-3 arylation of quinoxalin-2(1H)-ones with arylboronic acids is reported. This protocol is compatible with a wide range of functional groups and allows construction of various biologically important quinoxalin-2(1H)-one backbones.

[Ir(P-OP)]-catalyzed asymmetric hydrogenation of diversely substituted C=N-containing heterocycles

Iridium(I) complexes of enantiomerically pure phosphine-phosphite ligands ([Ir(Cl)(cod)(P - OP)]) efficiently catalyze the enantioselective hydrogenation of diverse C=N-containing heterocyclic compounds (benzoxazines, benzoxazinones, benzothiazinones, and quinoxalinones; 25 examples, up to 99% ee). A substrate-to-catalyst ratio as high as 2000:1 was reached.