50627-32-2

Upstream product

• 5625-52-5 1-methylpiperazin-2,5-dione 
• 115378-20-6 3-methoxy-2-pivalamidobenzoic acid 
• 90-04-0 2-methoxy-phenylamine 
• 33768-49-9 N-(2-methoxyphenyl)pivalamide 
• 65332-01-6 methyl N-(2-chloroacetyl)glycine 
• 3177-80-8 2-amino-3-methoxybenzoic acid 
• 1294456-01-1 C₁₄H₁₇ClN₂O₅ 
• 5121-34-6 methyl 2-amino-3-methoxybenzoate 
• 50627-31-1 2-iodo-3-methoxybenzoic acid 
• 186581-53-3 diazomethane 

Downstream Products

• 79247-66-8 C₂₉H₂₈N₂O₅S₂ 
• 79247-66-8 C₂₉H₂₈N₂O₅S₂ 
• 79247-67-9 C₂₁H₂₀N₂O₅S₂ 
• 79247-67-9 C₂₁H₂₀N₂O₅S₂ 
• 49593-04-6 (1R,3S,5R)-6-(2-Chloromethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 49593-04-6 (1R,3R,5R)-6-(2-Chloromethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 79247-65-7 (1S,3R,5S)-1-Benzyloxymethyl-6-(2-chloromethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 50627-34-4 3-methoxy-2-[3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-benzoic acid methyl ester 
• 79247-64-6 C₂₁H₂₀N₂O₄S₂ 
• 565433-79-6 2-(2,5-Bis-acetylsulfanyl-4-methyl-3,6-dioxo-piperazin-1-yl)-3-methoxy-benzoic acid methyl ester 
• 79247-63-5 (1R,5R)-6-(2-Hydroxymethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 1668-07-1 dl-dehydrogliotoxin 

Relevant academic research and scientific papers

A scaleable formal total synthesis of dehydrogliotoxin

A formal total synthesis of the epidithiodiketopiperazine natural product, dehydrogliotoxin (2), utilizing an intramolecular ring closure to form key intermediate 5 is described.

TOTAL SYNTHESIS OF GLIOTOXIN, DEHYDROGLIOTOXIN AND HYALODENDRIN

Two general methods, Method A and Method B in Scheme 19, to synthesize epidithiapiperazinediones, are described.A total synthesis of racemic and optically active gliotoxin (1) and of racemic dehydrogliotoxin (53) was achieved by using Method A, whereas a total synthesis of racemic hyalodendrin (52) was completed by using Method B.