65332-01-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2-[(2-Chloroacetyl)(methyl)amino]acetic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs, enhancing their therapeutic properties and effectiveness.
Used in Agrochemical Production:
In the agrochemical industry, 2-[(2-Chloroacetyl)(methyl)amino]acetic acid is used as a precursor in the production of agrochemicals, contributing to the development of more effective and targeted pest control agents.
Used in Chemical Manufacturing:
2-[(2-Chloroacetyl)(methyl)amino]acetic acid is utilized as a building block in the manufacturing of various chemicals, where its unique structure allows for the creation of a wide range of chemical compounds for different applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-[(2-Chloroacetyl)(methyl)amino]acetic acid is used as a research compound for the development of new drugs, providing a foundation for the design and synthesis of innovative pharmaceutical agents.

Upstream product

• 541-88-8 Chloroacetic anhydride 
• 107-97-1 sarcosine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 29816-01-1 Glycylsarcosine 
• 38082-70-1 N-methyl-N-(N-methyl-glycyl)-glycine 
• 106231-64-5 2-(benzoyloxy)-(N-methyl-N-acetic acid)acetamide 
• 162687-91-4 {[2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-acetyl]-methyl-amino}-acetic acid 
• 50627-32-2 3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester 
• 1294456-01-1 C₁₄H₁₇ClN₂O₅ 
• 155090-89-4 1-benzyl-3,6-dibromo-4-methylpiperazine-2,5-dione 
• 59136-05-9 1-benzyl-4-methylpiperazine-2,5-dione 
• 5625-52-5 1-methylpiperazin-2,5-dione 
• 162687-99-2 N'-<2-(morpholin-4-yl)ethyl>-N-<<(4,5-diphenyl-1H-imidazol-2-yl)thio>acetyl>sarcosinamide 
• 162687-92-5 2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-N-heptylcarbamoylmethyl-N-methyl-acetamide 
• 162688-00-8 N-[2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-ethyl]-N-methyl-N'-(2-morpholin-4-yl-ethyl)-ethane-1,2-diamine 
• 162687-93-6 4,5-diphenyl-2-<<2-amino>ethyl>thio>-1H-imidazole 

Relevant academic research and scientific papers

Studies toward luzopeptins: A key tripeptide subunit selectively deprotectable under neutral conditions

We describe a protocol for the multigram preparation of a tripeptide found in peptin antibiotics. The N-terminus is an azido group, while the C- terminus is an allyl ester. The molecule may be cleanly and selectively deblocked under neutral conditions, fa

PYRIDAZINIUM COMPOUNDS FOR USE IN A METHOD OF CONTROLLING UNWANTED PLANT GROWTH

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

A scaleable formal total synthesis of dehydrogliotoxin

A formal total synthesis of the epidithiodiketopiperazine natural product, dehydrogliotoxin (2), utilizing an intramolecular ring closure to form key intermediate 5 is described.

Design, Synthesis, and Structure-Activity Relationship Studies for a New Imidazole Series of J774 Macrophage Specific Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitors

Acyl-CoA:cholesterol acyltransferase (ACAT) is the primary enzyme involved in intracellular cholesterol esterification.Arterial wall infiltration by macrophages and subsequent uncontrolled esterification of cholesterol leading to foam cell formation is believed to be an important process which leads to the development of fatty streaks.Inhibitors of the ACAT enzyme may retard this atherogenic process.We have recently discovered a series of imidazoles which are potent in vitro ACAT inhibitors in the J774 macrophage cell culture assay.This paper will describe the design, synthesis, and structure-activity relationship for this very potent series of compounds.

Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis

This invention relates to imidazoles, namely, heterocycle-substituted amides, carbamates and ureas as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions containing them, and their use as antihypercholesterolemic and/or

Synthesis and Activity of New Epipolythiopiperazine-2,5-dione Compounds. I

The new lipophilic epipolythiopiperazine-2,5-diones 1,4-dibutylepidithiopiperazine-2,5-dione, 1,4-dibenzylepidithiopiperazine-2,5-dione, 1-benzyl-4-methylepidithiopiperazine-2,5-dione and 3,3'-dithiobis(1,4-dimethylpiperazine-2,5-dione) were synthesized.Unlike the parent compound, the fungal toxin and immunomodulating agent gliotoxin, these compounds did not affect macrophage adherence and cell proliferation in vitro.Like the reduced form of gliotoxin and other simple analogues, these new compounds induce oxidative damage to naked DNA.We conclude that an increase in lipophilicity plays no part in the biological activity of these compounds and in fact abrogates almost all activity.We also synthesized an intermolecular disulfide analogue which also lacked activity.

Halogenated acylamino acids as fungicides

Compounds of the formula STR1 wherein Y is chlorinated alkyl of 1 to 6 carbon atoms; wherein R is Cn H2n or R2 Cn H2n-1 wherein n is an integer of 1 to 11 and R2 is aralkyl or carboxyalky; and wherein R' is hydrogen, alkyl, haloalkyl, alkaryl or aryl; have fungicidal activity. The compounds can be used in the free acid or salt form.