50635-21-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-(2-Methylphenoxy)acetonitrile is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, leveraging its reactivity and properties to contribute to the development of new and improved products.
Used in Dye Production:
In the dye industry, 2-(2-Methylphenoxy)acetonitrile is employed for its ability to participate in a wide range of reactions, making it instrumental in the creation of diverse dyes with specific color characteristics.
Used in Perfumery:
2-(2-Methylphenoxy)acetonitrile is used as a component in the production of perfumes, capitalizing on its compatibility with various chemical processes to create unique and complex fragrances.
Used in Specialty Chemicals:
The versatile nature of 2-(2-Methylphenoxy)acetonitrile extends to the specialty chemicals sector, where it is used to produce a variety of compounds for specific applications, taking advantage of its unique reactivity and properties.

Upstream product

• 22560-43-6 ortho-methylphenoxyacetamide 
• 95-48-7 ortho-cresol 
• 590-17-0 cyanomethyl bromide 
• 107-14-2 chloroacetonitrile 
• 15516-43-5 (2-methylphenoxy)acetyl chloride 
• 1878-49-5 o-methylphenoxyacetic acid 

Downstream Products

• 35370-81-1 2-o-tolyloxy-thioacetamide 
• 1532534-46-5 1-(2,4-dihydroxy-5-propylphenyl)-2-(o-tolyloxy)ethanone 
• 1532534-20-5 1-(2,4-dihydroxy-5-methylphenyl)-2-(o-tolyloxy)ethanone 
• 137987-86-1 1-(2,4-dihydroxyphenyl)-2-(o-tolyloxy)ethanone 
• 1532533-97-3 C₁₅H₁₄O₅ 
• 1532533-38-2 1-(5-ethyl-2,4-dihydroxyphenyl)-2-(o-tolyloxy)ethanone 
• 137988-14-8 Acetic acid 4-oxo-3-o-tolyloxy-4H-chromen-7-yl ester 
• 137987-98-5 7-Hydroxy-3-o-tolyloxy-chromen-4-one 

Relevant academic research and scientific papers

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.

Cytosine analogues from substituted acetonitriles via Thorpe condensation

(Matrix presented) A Thorpe condensation is the key bond construction in a rapid and efficient synthesis of substituted cytosine derivatives from readily available starting materials.

Imidazoline-binding domains on monoamine oxidase B and subpopulations of enzyme

A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B-and its role in substrate processing. The rank order o