50638-48-7

Basic information

• Product Name: 4-BROMO-2,3-DIMETHYLANISOLE
• Synonyms: 1-broMo-4-Methoxy-2,3-diMethylbenzene;Benzene,1-broMo-4-Methoxy-2,3-diMethyl-;1-Bromo-2,3-dimethyl-4-methoxybenzene;4-Bromo-2,3-dimethylanisole 96%;4-BROMO-2,3-DIMETHYLANISOLE
• CAS NO: 50638-48-7
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.09
• Product Categories: Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 50638-48-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 197 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.36 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0254mmHg at 25°C
• Refractive Index: n20/D 1.566(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMO-2,3-DIMETHYLANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2,3-DIMETHYLANISOLE(50638-48-7)
• EPA Substance Registry System: 4-BROMO-2,3-DIMETHYLANISOLE(50638-48-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 50638-48-7(Hazardous Substances Data)

Usage

Uses

4-Bromo-2,3-dimethylanisole may be used in the preparation of:4,6-Dibromo-2,3-dimethylanisole via bromination using NBS-CH3CN system.4-Methoxy-2,2′,3,3′-tetramethyldiphenyl ether by reacting with 2,3-dimethylphenol.A novel arylsulfonamide derivative with potent glucocorticoid receptor (GR) agonist activity.

General Description

4-Bromo-2,3-dimethylanisole can be prepared from 2,3-dimethylanisole via bromination using N-bromosuccinimide-acetonitrile (NBS-CH3CN) system.

InChI:InChI=1/C9H11BrO/c1-6-7(2)9(11-3)5-4-8(6)10/h4-5H,1-3H3

Upstream product

• 22802-37-5 4-bromo-2,3-dimethylphenol 
• 74-88-4 methyl iodide 
• 526-75-0 2,3-Dimethylphenol 
• 2944-49-2 2,3-dimethylanisole 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1423617-03-1 3-bromo-6-methoxyphthalic acid 
• 1423617-06-4 4-bromo-2-(4-decylphenyl)-7-methoxyisoindoline-1,3-dione 
• 1423617-08-6 2-(4-decylphenyl)-4-methoxy-7-((trimethylsilyl)ethynyl)isoindoline-1,3-dione 
• 67291-62-7 2-methoxy-3.4-dimethylaniline 
• 92190-70-0 (4-Hydroxy-2,3-dimethyl-phenyl)-phenyl-sulfon 
• 108124-09-0 (4-Methoxy-2,3-dimethyl-phenyl)-phenyl-sulfon 
• 130662-49-6 Acetic acid 2-acetoxymethyl-3-bromo-6-methoxy-benzyl ester 
• 130662-50-9 (3-Bromo-2-hydroxymethyl-6-methoxy-phenyl)-methanol 
• 93349-66-7 1,2-Diamino-3-methoxy-4,5-dimethylbenzene 
• 86692-97-9 2,3-dimethyl-4-(2′,3′-dimethylphenoxy)phenol 
• 19164-83-1 1,4-dimethoxy-2,3-bis(bromomethyl)benzene 
• 934996-90-4 allyl 2,3-dimethyl-4-methoxyphenyl selenide 
• 39021-83-5 3,6-dimethoxy-o-xylene 
• 128141-64-0 4,6-Dibromo-1-methoxy-2,3-dimethylbenzene 

Relevant articles and documents

Highly Regioselective Bromination of 2,3-dimethylanisole with N-Bromosuccinimide

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CXCR3 RECEPTOR AGONISTS

Compounds are provided having the structure of the following Formula I: where R, R1, R2, R3a and R3b are as defined herein. Pharmaceutical compositions comprising such compounds, as well as methods related to their manufacture and use, are also provided.

Nickel-catalyzed decarbonylative polymerization of 5-alkynylphthalimides: A new methodology for the preparation of polyheterocycles

A nickel-catalyzed decarbonylative cycloaddition was developed, in which 5-alkynylphthalimides reacted to afford a new type of polyisoquinolone. It was demonstrated for the first time that decarbonylative cycloaddition can be an elementary process of polycondensation for the preparation of heterocyclic polymers.