50651-39-3Relevant articles and documents
Synthesis method of high-purity 2 - nitro -4-aminoanisole
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Paragraph 0057-0062, (2021/11/19)
The invention discloses a synthesis method of high-purity 2 -nitro -4-aminoanisole, wherein 2 - nitro -4-n-aminoanisole is synthesized through an assembly line. The assembly line comprises a reaction device, a discharging device and a cleaning device. The method comprises the following steps: A, feeding reaction raw materials into a reaction device for reaction. B, Use clear bottom device to carry out the stirring to phase transfer catalyst and reaction raw materials. C, Use the cleaning device to clean the bottom of reation kettle. D, The extrusion device is used to clean and blow the cleaning device and the bottom cleaning device, and the catalyst and the reaction raw material are pushed up and down. E: The extraction bucket is used to extract the product in the reaction liquid and the extracted reaction is continued to return to the reaction kettle. F, Use the discharging device to make the reaction all discharge. G, Wash the reaction liquid with the cleaning device, obtain the finished product.
Industrial production method for 2-amino-4-acetamidoanisole
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Paragraph 0055; 0060, (2018/04/03)
The invention discloses an industrial production method for 2-amino-4-acetamidoanisole. The industrial production method comprises the following steps: (1) allowing paranitroanisole and hydrogen to undergo a catalytic hydrogenation reduction reaction in the presence of a catalyst A so as to obtain p-aminoanisole; (2) allowing the p-aminoanisole to undergo an acetylation reaction so as to obtain p-acetamidoanisole; (3) allowing the p-acetamidoanisole to undergo a nitration reaction so as to obtain 2-nitro-4-acetamidoanisole; and (4) allowing 2-nitro-4-acetamidoanisole and hydrogen to undergo two catalytic hydrogenation reduction reactions in the presence of a catalyst B so as to obtain the 2-amino-4-acetamidoanisole. The production method provided by the invention has the characteristics oflow production cost, high reaction selectivity, simple separation process, high product purity, no three wastes in the process of production, recyclability and continuous large-scale industrial production, and solves the disadvantages of high separation cost, low product purity, and large discharge amount and difficult treatment of three wastes in the prior art.
Synthesis process of 2-amidogen-4-acetamido anisole
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Paragraph 0042-0043; 0046-0047; 0049-0050; 0052-0053, (2020/03/28)
The invention discloses a synthesis process of 2-amidogen-4-acetamido anisole. The synthesis process of the 2-amidogen-4-acetamido anisole comprises the steps of adopting p-methoxyaniline as a raw material, carrying out partial acylation reaction on the p-methoxyaniline and acetic anhydride, and preparing to obtain p-acetamido anisole; then carrying out nitration reaction, carrying out one-pot method'reaction to obtain 2-nitro-4-acetamido anisole, and under the action of a Pd/C catalyst, reducing the 2-nitro-4-acetamido anisole by adopting hydrazine monoformate as a hydrogen source to preparethe 2-amidogen-4-acetamido anisole. The synthesis process provided by the invention is low in energy consumption, low in cost, less in solid wastes and waste liquids, green and environmentally friendly, simple to operate, mild in reaction conditions, and high in industrial safety coefficient, the total yield of the target compound is 85 percent or above (on the basis of an initial reaction raw material), the HPLC (High Performance Liquid Chromatography) purity is 99.0 percent or above, the target compound is high in yield and good in quality, and the synthesis process is more suitable for industrial production.