50656-76-3

Usage

InChI:InChI=1/C5H7NO2/c1-3-2-4(7)6-5(3)8/h2,4,7H,1H3,(H,6,8)/t4-/m1/s1

Upstream product

• 109028-41-3 jatropham 5-O-β-D-glucopyranoside 
• 37772-60-4 5-hydroxy-3-methyl-1,5-dihydropyrrol-2-one 
• 1072-87-3 citraconimide 
• 108-05-4 vinyl acetate 
• 616-02-4 citraconic acid anhydride 

Relevant academic research and scientific papers

First synthesis of (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one (jatropham) by lipase-catalyzed kinetic resolution

Jatropham, (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one, is synthesized in three steps from citraconic anhydride. Highly regioselective reduction of citraconimide gives racemic jatropham in high yield. Kinetic resolution of racemic jatropham using lipase is also described. (C) 1999 Elsevier Science Ltd.

Convenient route to both enantiomers of chiral 5-hydroxypyrrolidin-2-one and 5-hydroxy-1,5-dihydropyrrol-2-one: Reverse enantioselectivity in lipase-catalyzed kinetic resolution

High enantioselectivity was achieved in the lipase-catalyzed kinetic resolution of 5-hydroxypyrrolidin-2-one and 5-hydroxy-1,5-dihydropyrrol-2-one derivatives. Lipase PS and Novozym 435 were the successful catalysts (E=>1000). The acetylation of the N-pro

JATROPHAM GLUCOSIDE FROM THE BULBS OF LILIUM HANSONII

From the methanolic extract of the fresh bulbs of Lilium hansonii, a new glucoside, jatropham 5-O-β-D-glucopyranoside, was isolated together with jatropham and (+/-)-5-O-methyljatropham. Key Word Index--Lilium hansonii; liliaceae; jatropham; jatropham 5-O-β-D-glucopyranoside; (+/-)-5-O-methyljatropham; antitumor alkaloid.