First synthesis of (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one (jatropham) by lipase-catalyzed kinetic resolution

DOI: 10.1016/S0957-4166(99)00513-3

Source and publish data:

Tetrahedron Asymmetry p. 4469 - 4471 (1999)

Update date:2022-08-23

Topics:

Authors:

Mase, Nobuyuki

Nishi, Toshiki

Takamori, Yasuaki

Yoda, Hidemi

Takabe, Kunihiko

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Article abstract of DOI:10.1016/S0957-4166(99)00513-3

Jatropham, (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one, is synthesized in three steps from citraconic anhydride. Highly regioselective reduction of citraconimide gives racemic jatropham in high yield. Kinetic resolution of racemic jatropham using lipase is also described. (C) 1999 Elsevier Science Ltd.

Full text of DOI:10.1016/S0957-4166(99)00513-3

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