50677-28-6

Upstream product

• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 79-04-9 chloroacetyl chloride 
• 79-11-8 chloroacetic acid 
• 62-23-7 4-nitro-benzoic acid 
• 99-77-4 ethyl 4-nitrobenzoate 

Downstream Products

• 50677-30-0 2-(chloromethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole 
• 83070-35-3 2-p-nitrophenyl-4H,6H-1,3,4-oxadiazin-5-one 
• 120354-53-2 4-(4-Bromo-butyl)-2-(4-nitro-phenyl)-4H-[1,3,4]oxadiazin-5-one 
• 120354-51-0 5-[2-(4-Nitro-phenyl)-5-oxo-5,6-dihydro-[1,3,4]oxadiazin-4-yl]-pentanenitrile 
• 120354-54-3 5-[2-(4-Nitro-phenyl)-5-oxo-5,6-dihydro-[1,3,4]oxadiazin-4-yl]-pentanoic acid methyl ester 
• 50677-41-3 1-[5-(4-nitro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-piperidine 
• 50677-40-2 2-(4-nitro-phenyl)-5-pyrrolidin-1-ylmethyl-[1,3,4]oxadiazole 

Relevant academic research and scientific papers

Synthesis, Molecular Docking and Biological Evaluation of 2-Aryloxy-N-Phenylacetamide and N′-(2-Aryloxyoxyacetyl) Benzohydrazide Derivatives as Potential Antibacterial Agents

A new class of 2-aryloxy-N-phenylacetamide and N′-(2-aryloxyoxyacetyl) benzohydrazide derivatives with different active moieties were synthesized and screened for their antibacterial activity. Structural characterization of synthesized compounds was perfo

Synthesis of pyrimidones and evaluation of their xanthine oxidase inhibitory and antioxidant activities

The increasing prevalence of gout has been accompanied by a growing number of patients intolerant to or with disease refractory to the available urate-lowering therapies. This metabolic disease is a common disease with a higher prevalence in men older than 30 years and in women older than 50 years. These findings highlight the need for emerging treatments to effectively lower urate levels. In this view, we describe the xanthine oxidase (XO) inhibitory activities of the synthesized compounds 5a-j and also their antioxidant activities. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. On the other hand, compounds 5g and 5j exhibited moderate antioxidant activity. In order to find new urate-lowering compounds, the xanthine oxidase (XO) inhibitory and antioxidant activities of the newly synthesized pyrimidones 5a-j were evaluated. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. In addition, compounds 5g and 5j showed moderate antioxidant activity.

Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones

A total of 20 new compounds containing the oxadiazolyl 3(2H)-pyridazinone moiety were synthesized. The structures of all the compounds were confirmed by 1H NMR, IR, MS, and elemental analysis. Their insect antifeedant activities against Asiatic corn borer Ostrinia furnacalis (Guenee) were examined and compared with commercial azadirachtin. The compounds exhibited significant levels of activity. The feeding deterrency values of IIIa,j were 57% and 51% at 500 mg/kg concentration, respectively.

Synthesis and insecticidal activity of neonicotinoids derivatives

A new class of compounds- neonicotinoids containing oxadiazole -were synthesized and characterized by using 1H NMR, IR, MS and Elemental Analysis. Their insecticidal activities were tested against Mythimna separata Walker and Aphis rumicis Linnaeus, some of them showed some insecticidal activity.