50691-29-7

Basic information

• Product Name: 1H-Pyrrole, 1-(2-phenylethyl)-
• CAS NO: 50691-29-7
• Molecular Formula: C12H13N
• Molecular Weight: 171.242
• Mol File: 50691-29-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-(2-phenylethyl)-(50691-29-7)
• EPA Substance Registry System: 1H-Pyrrole, 1-(2-phenylethyl)-(50691-29-7)

Safety Data

• Hazardous Substances Data: 50691-29-7(Hazardous Substances Data)

Usage

Structure

A derivative of pyrrole, a five-membered aromatic heterocyclic organic compound with a phenylethyl group attached to the nitrogen atom.

Usage

Commonly used in organic synthesis and has potential applications in the pharmaceutical and agrochemical industries.

Biological activities

The compound and its derivatives may have various biological activities, including potential as anti-inflammatory, antimicrobial, and anticancer agents.

Synthesis applications

May be used as a building block in the synthesis of more complex organic molecules.

Upstream product

• 1589-82-8 phenylmagnesium bromide 
• 124337-35-5 1-Pyrrol-1-ylmethyl-1H-benzotriazole 
• 124337-61-7 1-(2-Phenyl-1-pyrrol-1-yl-ethyl)-1H-benzotriazole 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 64-04-0 phenethylamine 
• 63-91-2 L-phenylalanine 
• 134454-31-2 (2E,4RS,5RS)-(±)-4,5-epoxy-(E)-2-decenal 
• 78307-41-2 4,5(E)-epoxy-2(E)-heptenal 
• 110-65-6 1,4-dihydroxybut-2-yne 
• 110-63-4 Butane-1,4-diol 
• 109-97-7 pyrrole 
• 3558-60-9 1-methoxy-2-phenylethane 

Downstream Products

• 114078-19-2 methyl 2-[N-(2-phenyl-ethyl)pyrrol-2-yl)-2-oxoacetate 
• 1118758-09-0 2,2,2-trichloro-1-(1-phenethyl-1H-pyrrol-2-yl)-ethanone 
• 49795-42-8 1-phenethyl-1H-pyrrole-2-carbaldehyde 

Relevant articles and documents

Volatiles from the Psychrotolerant Bacterium Chryseobacterium polytrichastri

The flavobacterium Chryseobacterium polytrichastri was investigated for its volatile profile by use of a closed-loop stripping apparatus (CLSA) and subsequent GC-MS analysis. The analyses revealed a rich headspace extract with 71 identified compounds. Compound identification was based on a comparison to library mass spectra for known compounds and on a synthesis of authentic standards for unknowns. Important classes were phenylethyl amides and a series of corresponding imines and pyrroles.

Sustainable Manganese-Catalyzed Solvent-Free Synthesis of Pyrroles from 1,4-Diols and Primary Amines

A general and selective metal-catalyzed conversion of biomass-derived primary diols and amines to the highly valuable 2,5-unsubstituted pyrroles has been developed. The reaction is catalyzed by a stable nonprecious manganese complex (1 mol %) in the absence of organic solvents whereby water and molecular hydrogen are the only side products. The manganese catalyst shows unprecedented selectivity, avoiding the formation of pyrrolidines, cyclic imides, and lactones.

Sustainable Pathways to Pyrroles through Iron-Catalyzed N-Heterocyclization from Unsaturated Diols and Primary Amines

Pyrroles are prominent scaffolds in pharmaceutically active compounds and play an important role in medicinal chemistry. Therefore, the development of new, atom-economic, and sustainable catalytic strategies to obtain these moieties is highly desired. Direct catalytic pathways that utilize readily available alcohol substrates have been recently established; however, these approaches rely on the use of noble metals such as ruthenium or iridium. Here, we report on the direct synthesis of pyrroles using a catalyst based on the earth-abundant and inexpensive iron. The method uses 2-butyne-1,4-diol or 2-butene-1,4-diol that can be directly coupled with anilines, benzyl amines, and aliphatic amines to obtain a variety of N-substituted pyrroles in moderate-to-excellent isolated yields.